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Mouse Anti-SRSF5 Recombinant Antibody (CBXS-3757) (CBMAB-S1030-CQ)


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Summary

Host Animal
Mouse
Specificity
Dog, Chicken, Human, Mouse, Rabbit, Rat, Frog
Clone
CBXS-3757
Antibody Isotype
IgG1, κ
Application
ELISA, ICC, IF, WB

Basic Information

Immunogen
Purified, de-phosphorylated bovine Srp55 and Drosophila p55-GST. The 16H3 epitope has been mapped to a 40-amino acid polypeptide composed almost exclusively of arginine alternating with glutamate and aspartate
Specificity
Dog, Chicken, Human, Mouse, Rabbit, Rat, Frog
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.1% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serine And Arginine Rich Splicing Factor 5
Introduction
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human6430
Mouse20384
Rat29667
Frog448003
Dog490754
Chicken423258
Rabbit100340192
UniProt ID
HumanQ13243
MouseO35326
RatQ09167
FrogQ6DK94
DogA0A8I3MVR0
ChickenE1BY00
RabbitG1SWW7
Alternative Names
Serine And Arginine Rich Splicing Factor 5; Splicing Factor, Arginine/Serine-Rich 5; Serine/Arginine-Rich Splicing Factor 5; Pre-MRNA-Splicing Factor SRP40; Delayed-Early Protein HRS; SR Splicing Factor 5; SFRS5; SRP40; HRS;
Function
Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
Biological Process
Biological Process cellular response to insulin stimulusIEA:Ensembl
Biological Process liver regenerationIEA:Ensembl
Biological Process mRNA processingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process mRNA splice site selectionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of RNA splicingIEA:Ensembl
Biological Process regulation of cell cycleIEA:Ensembl
Cellular Location
Nucleus
PTM
Extensively phosphorylated on serine residues in the RS domain.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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