SSNA1

SSNA1 (SS Nuclear Autoantigen 1) is a Protein Coding gene. Diseases associated with SSNA1 include Chronic Laryngitis and Paralytic Squint. Among its related pathways are Cell Cycle, Mitotic and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include identical protein binding.

Full Name

SS Nuclear Autoantigen 1

Function

Microtubule-binding protein which stabilizes dynamic microtubules by slowing growth and shrinkage at both plus and minus ends and serves as a sensor of microtubule damage, protecting microtubules from the microtubule-severing enzyme SPAST (PubMed:34970964).
Induces microtubule branching which is mediated by the formation of long SSNA1 fibrils which guide microtubule protofilaments to split apart from the mother microtubule and form daughter microtubules (By similarity).
Plays a role in axon outgrowth and branching (PubMed:25390646).
Required for cell division (PubMed:25390646).

Biological Process

Biological Process axon arborizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process axon extensionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process axonogenesisISS:UniProtKB
Biological Process cell divisionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ciliary receptor clustering involved in smoothened signaling pathwayIEA:Ensembl
Biological Process intraciliary transportIEA:Ensembl
Biological Process microtubule cytoskeleton organizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process microtubule nucleationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Midbody
Cytoplasm, cytoskeleton, flagellum basal body
Cytoplasm, cytoskeleton, flagellum axoneme
Cell projection, axon
In sperm, strongly expressed in the basal body region with weaker expression in the axoneme (PubMed:12640030).
Localizes to axon branching points in neurons (By similarity).