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Mouse Anti-SSNA1 Recombinant Antibody (CBXS-4676) (CBMAB-S1911-CQ)

This product is a mouse antibody that recognizes SSNA1. The antibody CBXS-4676 can be used for immunoassay techniques such as: Dot, ICC, WB.
See all SSNA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4676
Antibody Isotype
IgG2a
Application
Dot, ICC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 1% BSA
Preservative
0.05% sodium azide
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SS Nuclear Autoantigen 1
Introduction
SSNA1 (SS Nuclear Autoantigen 1) is a Protein Coding gene. Diseases associated with SSNA1 include Sjogren Syndrome and Chronic Laryngitis. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. Gene Ontology (GO) annotations related to this gene include identical protein binding.
Entrez Gene ID
8636
UniProt ID
O43805
Alternative Names
SS Nuclear Autoantigen 1; Sjogrens Syndrome Nuclear Autoantigen 1; Sjogren Syndrome Nuclear Autoantigen 1; Nuclear Autoantigen Of 14 KDa; NA14; Sjoegren Syndrome Nuclear Autoantigen 1; NA-14; N14;
Function
Microtubule-binding protein which stabilizes dynamic microtubules by slowing growth and shrinkage at both plus and minus ends and serves as a sensor of microtubule damage, protecting microtubules from the microtubule-severing enzyme SPAST (PubMed:34970964).
Induces microtubule branching which is mediated by the formation of long SSNA1 fibrils which guide microtubule protofilaments to split apart from the mother microtubule and form daughter microtubules (By similarity).
Plays a role in axon outgrowth and branching (PubMed:25390646).
Required for cell division (PubMed:25390646).
Biological Process
Biological Process axon arborizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process axon extensionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process axonogenesisISS:UniProtKB
Biological Process cell divisionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ciliary receptor clustering involved in smoothened signaling pathwayIEA:Ensembl
Biological Process intraciliary transportIEA:Ensembl
Biological Process microtubule cytoskeleton organizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process microtubule nucleationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Midbody
Cytoplasm, cytoskeleton, flagellum basal body
Cytoplasm, cytoskeleton, flagellum axoneme
Cell projection, axon
In sperm, strongly expressed in the basal body region with weaker expression in the axoneme (PubMed:12640030).
Localizes to axon branching points in neurons (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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