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SSRP1

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]

Full Name

Structure Specific Recognition Protein 1

Function

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.

Biological Process

Biological Process DNA repairIEA:UniProtKB-KW
Biological Process DNA replicationIEA:UniProtKB-KW
Biological Process nucleosome assembly1 PublicationIC:ComplexPortal
Biological Process nucleosome disassemblyManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process regulation of chromatin organizationManual Assertion Based On ExperimentIDA:CACAO

Cellular Location

Nucleus
Nucleus, nucleolus
Chromosome
Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.

PTM

Phosphorylated by CK2 following UV but not gamma irradiation. Phosphorylation inhibits its DNA-binding activity.
Ubiquitinated. Polyubiquitinated following caspase cleavage resulting in degradation of the N-terminal ubiquitinated part of the cleaved protein.
Sumoylated.

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Anti-SSRP1 antibodies

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Rabbit Anti-SSRP1 Recombinant Antibody (CBXS-1588) (CBMAB-S4437-CQ)

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Target: SSRP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBXS-1588

Application*: WB, IF

Rabbit Anti-SSRP1 Recombinant Antibody (CBXS-1587) (CBMAB-S4436-CQ)

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Target: SSRP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBXS-1587

Application*: WB, F

Mouse Anti-SSRP1 Recombinant Antibody (CBXS-4864) (CBMAB-S2087-CQ)

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Target: SSRP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4864

Application*: WB, IP

Mouse Anti-SSRP1 Recombinant Antibody (CBXS-3619) (CBMAB-S0904-CQ)

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Target: SSRP1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-3619

Application*: WB, IP, F, IF

Mouse Anti-SSRP1 Recombinant Antibody (CBXS-3612) (CBMAB-S0897-CQ)

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Target: SSRP1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXS-3612

Application*: WB, CI, IP, IF

Rabbit Anti-SSRP1 Recombinant Antibody (CBXS-6012) (CBMAB-S0858-CQ)

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Target: SSRP1

Host: Rabbit

Specificity: Human, Mouse, Rat, Monkey, Chicken

Clone: CBXS-6012

Application*: WB, CI

Human Anti-SSRP1 Recombinant Antibody (CBXS-3566) (CBMAB-S0391-CQ)

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Target: SSRP1

Host: Human

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBXS-3566

Application*: F

Mouse Anti-SSRP1 Recombinant Antibody (3E4) (CBMAB-F2243-CQ)

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Target: SSRP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3E4

Application*: WB

Mouse Anti-SSRP1 Recombinant Antibody (CBXF-3578) (CBMAB-F2084-CQ)

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Target: SSRP1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXF-3578

Application*: IF, IP, WB

Mouse Anti-SSRP1 Recombinant Antibody (CBXF-2367) (CBMAB-F0703-CQ)

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Target: SSRP1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXF-2367

Application*: WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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