Rabbit Anti-SSRP1 Recombinant Antibody (CBXS-6012) (CBMAB-S0858-CQ)

Name: Rabbit Anti-SSRP1 Recombinant Antibody (CBXS-6012)
SKU: CBMAB-S0858-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Rabbit

Clone

CBXS-6012

Application

WB, ChIP

Specificity

Human, Mouse, Rat, Monkey, Chicken

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Structure Specific Recognition Protein 1

Introduction

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.

Entrez Gene ID

Human	6749
Mouse	20833
Rat	81785
Monkey	706614
Chicken	396509

UniProt ID

Human	Q08945
Mouse	Q08943
Rat	Q04931
Monkey	F7E0V3
Chicken	Q04678

Alternative Names

Structure Specific Recognition Protein 1; Chromatin-Specific Transcription Elongation Factor 80 KDa Subunit; Facilitates Chromatin Transcription Complex 80 KDa Subunit; Facilitates Chromatin Transcription Complex Subunit SSRP1; Recombination Signal Sequence Recognition Protein 1; Facilitates Chromatin Remodeling 80 KDa Subunit; FACT 80 KDa Subunit; FACTp80; FACT80;

Function

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.

Biological Process

Biological Process DNA repairIEA:UniProtKB-KW
Biological Process DNA replicationIEA:UniProtKB-KW
Biological Process nucleosome assembly1 PublicationIC:ComplexPortal
Biological Process nucleosome disassemblyManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process regulation of chromatin organizationManual Assertion Based On ExperimentIDA:CACAO

Cellular Location

Nucleus
Nucleus, nucleolus
Chromosome
Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.

PTM

Phosphorylated by CK2 following UV but not gamma irradiation. Phosphorylation inhibits its DNA-binding activity.
Ubiquitinated. Polyubiquitinated following caspase cleavage resulting in degradation of the N-terminal ubiquitinated part of the cleaved protein.
Sumoylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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