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Mouse Anti-SSRP1 Recombinant Antibody (CBXS-4864) (CBMAB-S2087-CQ)

This product is a mouse antibody that recognizes SSRP1. The antibody CBXS-4864 can be used for immunoassay techniques such as: WB, IP.
See all SSRP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4864
Antibody Isotype
IgG1
Application
WB, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Structure Specific Recognition Protein 1
Introduction
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.
Entrez Gene ID
6749
UniProt ID
Q08945
Alternative Names
Structure Specific Recognition Protein 1; Chromatin-Specific Transcription Elongation Factor 80 KDa Subunit; Facilitates Chromatin Transcription Complex 80 KDa Subunit; Facilitates Chromatin Transcription Complex Subunit SSRP1; Recombination Signal Sequence Recognition Protein 1; Facilitates Chromatin Remodeling 80 KDa Subunit; FACT 80 KDa Subunit; FACTp80; FACT80;
Function
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.
Biological Process
Biological Process DNA repairIEA:UniProtKB-KW
Biological Process DNA replicationIEA:UniProtKB-KW
Biological Process nucleosome assembly1 PublicationIC:ComplexPortal
Biological Process nucleosome disassemblyManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process regulation of chromatin organizationManual Assertion Based On ExperimentIDA:CACAO
Cellular Location
Nucleus
Nucleus, nucleolus
Chromosome
Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
PTM
Phosphorylated by CK2 following UV but not gamma irradiation. Phosphorylation inhibits its DNA-binding activity.
Ubiquitinated. Polyubiquitinated following caspase cleavage resulting in degradation of the N-terminal ubiquitinated part of the cleaved protein.
Sumoylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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