SULF1

This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants.

Full Name

Sulfatase 1

Function

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.

Biological Process

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process bone developmentISS:BHF-UCL
Biological Process cartilage developmentISS:UniProtKB
Biological Process chondrocyte developmentISS:UniProtKB
Biological Process embryonic skeletal system developmentISS:UniProtKB
Biological Process esophagus smooth muscle contractionISS:UniProtKB
Biological Process glial cell-derived neurotrophic factor receptor signaling pathwayISS:UniProtKB
Biological Process glomerular basement membrane developmentISS:UniProtKB
Biological Process glomerular filtrationISS:UniProtKB
Biological Process heparan sulfate proteoglycan metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process innervationISS:UniProtKB
Biological Process kidney developmentISS:BHF-UCL
Biological Process negative regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of endothelial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of prostatic bud formationISS:UniProtKB
Biological Process positive regulation of BMP signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of vascular endothelial growth factor productionISS:UniProtKB
Biological Process positive regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process vascular endothelial growth factor receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Endoplasmic reticulum
Golgi apparatus, Golgi stack
Cell surface
Also localized on the cell surface.

PTM

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.