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Mouse Anti-SULF1 Recombinant Antibody (CBXS-0841) (CBMAB-S3765-CQ)

This product is a mouse antibody that recognizes SULF1. The antibody CBXS-0841 can be used for immunoassay techniques such as: ELISA, WB.
See all SULF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0841
Antibody Isotype
IgM, κ
Application
ELISA, WB

Basic Information

Immunogen
SULF1 (NP_055985.1, 780 a.a.-871 a.a) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascites fluid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sulfatase 1
Introduction
This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
23213
UniProt ID
Q8IWU6
Alternative Names
SULF-1
Function
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process bone developmentISS:BHF-UCL
Biological Process cartilage developmentISS:UniProtKB
Biological Process chondrocyte developmentISS:UniProtKB
Biological Process embryonic skeletal system developmentISS:UniProtKB
Biological Process esophagus smooth muscle contractionISS:UniProtKB
Biological Process glial cell-derived neurotrophic factor receptor signaling pathwayISS:UniProtKB
Biological Process glomerular basement membrane developmentISS:UniProtKB
Biological Process glomerular filtrationISS:UniProtKB
Biological Process heparan sulfate proteoglycan metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process innervationISS:UniProtKB
Biological Process kidney developmentISS:BHF-UCL
Biological Process negative regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of endothelial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of prostatic bud formationISS:UniProtKB
Biological Process positive regulation of BMP signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of vascular endothelial growth factor productionISS:UniProtKB
Biological Process positive regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process vascular endothelial growth factor receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum
Golgi apparatus, Golgi stack
Cell surface
Also localized on the cell surface.
PTM
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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