Human SULF1 ELISA Kit (V2LY-0626-LY4569)

Sulfatase 1

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process bone developmentISS:BHF-UCL
Biological Process cartilage developmentISS:UniProtKB
Biological Process chondrocyte developmentISS:UniProtKB
Biological Process embryonic skeletal system developmentISS:UniProtKB
Biological Process esophagus smooth muscle contractionISS:UniProtKB
Biological Process glial cell-derived neurotrophic factor receptor signaling pathwayISS:UniProtKB
Biological Process glomerular basement membrane developmentISS:UniProtKB
Biological Process glomerular filtrationISS:UniProtKB
Biological Process heparan sulfate proteoglycan metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process innervationISS:UniProtKB
Biological Process kidney developmentISS:BHF-UCL
Biological Process negative regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of endothelial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of prostatic bud formationISS:UniProtKB
Biological Process positive regulation of BMP signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of vascular endothelial growth factor productionISS:UniProtKB
Biological Process positive regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process vascular endothelial growth factor receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB

Endoplasmic reticulum
Golgi apparatus, Golgi stack
Cell surface
Also localized on the cell surface.

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.