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TBX18

TBX18 is a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. TBX18 belongs to the vertebrate specific Tbx1 sub-family. TBX18 acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. TBX18 forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors.

Full Name

T-Box 18

Function

Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area.

Biological Process

Biological Process cell fate specificationIBA:GO_Central1 Publication
Biological Process cochlea morphogenesisISS:ARUK-UCL
Biological Process morphogenesis of embryonic epitheliumIBA:GO_Central1 Publication
Biological Process negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formationISS:BHF-UCL
Biological Process positive regulation of DNA-templated transcriptionIEA:InterPro
Biological Process regulation of SA node cell action potentialIMP:BHF-UCL1 Publication
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process sinoatrial node cell developmentIMP:BHF-UCL1 Publication
Biological Process sinoatrial node cell fate commitmentIMP:BHF-UCL1 Publication
Biological Process sinoatrial node developmentISS:BHF-UCL
Biological Process smooth muscle cell differentiationISS:ARUK-UCL
Biological Process somitogenesisISS:ARUK-UCL
Biological Process ureter developmentIMP:UniProtKB1 Publication

Cellular Location

Nucleus

Involvement in disease

Congenital anomalies of kidney and urinary tract 2 (CAKUT2):
A disorder encompassing a broad spectrum of renal and urinary tract malformations that include renal agenesis, kidney hypodysplasia, multicystic kidney dysplasia, duplex collecting system, posterior urethral valves and ureter abnormalities. Congenital anomalies of kidney and urinary tract are the commonest cause of chronic kidney disease in children.

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Anti-TBX18 antibodies

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Mouse Anti-TBX18 Recombinant Antibody (4D3) (CBMAB-A8907-LY)

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Target: TBX18

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4D3

Application*: WB, E

Mouse Anti-TBX18 Recombinant Antibody (3G2) (CBMAB-A8906-LY)

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Target: TBX18

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: 3G2

Application*: WB, E

Mouse Anti-TBX18 Recombinant Antibody (3D9) (CBMAB-A8905-LY)

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Target: TBX18

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: 3D9

Application*: WB, E

Mouse Anti-TBX18 Recombinant Antibody (3C12) (CBMAB-A8904-LY)

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Target: TBX18

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: 3C12

Application*: WB, E

Mouse Anti-TBX18 Recombinant Antibody (1A1) (CBMAB-A8903-LY)

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Target: TBX18

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1A1

Application*: WB, E

Mouse Anti-TBX18 Recombinant Antibody (CBYJT-2135) (CBMAB-T1238-YJ)

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Target: TBX18

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: CBYJT-2135

Application*: IF, E, WB

Mouse Anti-TBX18 Recombinant Antibody (CBYJT-2134) (CBMAB-T1237-YJ)

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Target: TBX18

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: CBYJT-2134

Application*: E, WB

Mouse Anti-TBX18 Recombinant Antibody (CBYJT-2133) (CBMAB-T1236-YJ)

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Target: TBX18

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYJT-2133

Application*: WB, E, IC, IF

Mouse Anti-TBX18 Recombinant Antibody (CBYJT-2132) (CBMAB-T1235-YJ)

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Target: TBX18

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-2132

Application*: WB, IP, IF, E

Mouse Anti-TBX18 Recombinant Antibody (CBYJT-2131) (CBMAB-T1234-YJ)

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Target: TBX18

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-2131

Application*: IC

Mouse Anti-TBX18 Recombinant Antibody (CBYJT-2130) (CBMAB-T1233-YJ)

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Target: TBX18

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-2130

Application*: WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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