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Mouse Anti-TBX18 Recombinant Antibody (CBYJT-2130) (CBMAB-T1233-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TBX18 (T-Box 18). The antibody can be used for immunoassay techniques, such as WB.
See all TBX18 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2130
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant human TBX18, Ala384-Ser504, Accession # O95935
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 384-504

Target

Full Name
T-Box 18
Introduction
TBX18 is a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. TBX18 belongs to the vertebrate specific Tbx1 sub-family. TBX18 acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. TBX18 forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors.
Entrez Gene ID
9096
UniProt ID
O95935
Alternative Names
T-Box 18; T-Box Protein 18; T-Box Transcription Factor TBX18; CAKUT2
Function
Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area.
Biological Process
Biological Process cell fate specificationIBA:GO_Central1 Publication
Biological Process cochlea morphogenesisISS:ARUK-UCL
Biological Process morphogenesis of embryonic epitheliumIBA:GO_Central1 Publication
Biological Process negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formationISS:BHF-UCL
Biological Process positive regulation of DNA-templated transcriptionIEA:InterPro
Biological Process regulation of SA node cell action potentialIMP:BHF-UCL1 Publication
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process sinoatrial node cell developmentIMP:BHF-UCL1 Publication
Biological Process sinoatrial node cell fate commitmentIMP:BHF-UCL1 Publication
Biological Process sinoatrial node developmentISS:BHF-UCL
Biological Process smooth muscle cell differentiationISS:ARUK-UCL
Biological Process somitogenesisISS:ARUK-UCL
Biological Process ureter developmentIMP:UniProtKB1 Publication
Cellular Location
Nucleus
Involvement in disease
Congenital anomalies of kidney and urinary tract 2 (CAKUT2):
A disorder encompassing a broad spectrum of renal and urinary tract malformations that include renal agenesis, kidney hypodysplasia, multicystic kidney dysplasia, duplex collecting system, posterior urethral valves and ureter abnormalities. Congenital anomalies of kidney and urinary tract are the commonest cause of chronic kidney disease in children.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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