TBXA2R

TBXA2R is a member of the G protein-coupled receptor family. TBXA2R interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in TBXA2R results in a bleeding disorder.

Full Name

Thromboxane A2 Receptor

Function

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C.
Isoform 1
Activates adenylyl cyclase.
Isoform 2
Inhibits adenylyl cyclase.

Biological Process

Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayIBA:GO_Central1 Publication
Biological Process cellular response to lipopolysaccharideIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathwayTAS:ProtInc1 Publication
Biological Process inflammatory responseIBA:GO_Central1 Publication
Biological Process negative regulation of cell migration involved in sprouting angiogenesisIGI:BHF-UCL1 Publication
Biological Process positive regulation of angiogenesisIEA:Ensembl
Biological Process positive regulation of blood coagulationIEA:Ensembl
Biological Process positive regulation of blood pressureIBA:GO_Central1 Publication
Biological Process positive regulation of cytosolic calcium ion concentrationIBA:GO_Central1 Publication
Biological Process positive regulation of smooth muscle contractionIEA:Ensembl
Biological Process positive regulation of vasoconstrictionIBA:GO_Central1 Publication
Biological Process response to ethanolIEA:Ensembl
Biological Process response to nutrientIEA:Ensembl
Biological Process response to testosteroneIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process second-messenger-mediated signalingIEA:Ensembl
Biological Process smooth muscle contractionIEA:Ensembl

Cellular Location

Cell membrane

Involvement in disease

Bleeding disorder, platelet-type, 13 (BDPLT13):
A disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding.

Topology

Extracellular: 1-29
Helical: 30-52
Cytoplasmic: 53-66
Helical: 67-87
Extracellular: 88-106
Helical: 107-128
Cytoplasmic: 129-149
Helical: 150-172
Extracellular: 173-193
Helical: 194-219
Cytoplasmic: 220-246
Helical: 247-270
Extracellular: 271-289
Helical: 290-311
Cytoplasmic: 312-343