Human TBXA2R ELISA Kit (V2LY-0626-LY5328)

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Tested Data
Request for COA
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Basic Information

Sensitivity
0.0075 ng/mL
Detection Range
0.015-3 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
37.4 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Thromboxane A2 Receptor
Function
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C.
Isoform 1
Activates adenylyl cyclase.
Isoform 2
Inhibits adenylyl cyclase.
Biological Process
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayIBA:GO_Central1 Publication
Biological Process cellular response to lipopolysaccharideIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathwayTAS:ProtInc1 Publication
Biological Process inflammatory responseIBA:GO_Central1 Publication
Biological Process negative regulation of cell migration involved in sprouting angiogenesisIGI:BHF-UCL1 Publication
Biological Process positive regulation of angiogenesisIEA:Ensembl
Biological Process positive regulation of blood coagulationIEA:Ensembl
Biological Process positive regulation of blood pressureIBA:GO_Central1 Publication
Biological Process positive regulation of cytosolic calcium ion concentrationIBA:GO_Central1 Publication
Biological Process positive regulation of smooth muscle contractionIEA:Ensembl
Biological Process positive regulation of vasoconstrictionIBA:GO_Central1 Publication
Biological Process response to ethanolIEA:Ensembl
Biological Process response to nutrientIEA:Ensembl
Biological Process response to testosteroneIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process second-messenger-mediated signalingIEA:Ensembl
Biological Process smooth muscle contractionIEA:Ensembl
Cellular Location
Cell membrane
Involvement in disease
Bleeding disorder, platelet-type, 13 (BDPLT13):
A disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding.
Topology
Extracellular: 1-29
Helical: 30-52
Cytoplasmic: 53-66
Helical: 67-87
Extracellular: 88-106
Helical: 107-128
Cytoplasmic: 129-149
Helical: 150-172
Extracellular: 173-193
Helical: 194-219
Cytoplasmic: 220-246
Helical: 247-270
Extracellular: 271-289
Helical: 290-311
Cytoplasmic: 312-343
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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