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Mouse Anti-TBXA2R Recombinant Antibody (CBYJT-2176) (CBMAB-T1281-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TBXA2R (Thromboxane A2 Receptor). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all TBXA2R antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2176
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Thromboxane A2 Receptor
Introduction
TBXA2R is a member of the G protein-coupled receptor family. TBXA2R interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in TBXA2R results in a bleeding disorder.
Entrez Gene ID
6915
UniProt ID
P21731
Alternative Names
Thromboxane A2 Receptor; Prostanoid TP Receptor; TXA2-R; BDPLT13
Function
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C.
Isoform 1
Activates adenylyl cyclase.
Isoform 2
Inhibits adenylyl cyclase.
Biological Process
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayIBA:GO_Central1 Publication
Biological Process cellular response to lipopolysaccharideIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathwayTAS:ProtInc1 Publication
Biological Process inflammatory responseIBA:GO_Central1 Publication
Biological Process negative regulation of cell migration involved in sprouting angiogenesisIGI:BHF-UCL1 Publication
Biological Process positive regulation of angiogenesisIEA:Ensembl
Biological Process positive regulation of blood coagulationIEA:Ensembl
Biological Process positive regulation of blood pressureIBA:GO_Central1 Publication
Biological Process positive regulation of cytosolic calcium ion concentrationIBA:GO_Central1 Publication
Biological Process positive regulation of smooth muscle contractionIEA:Ensembl
Biological Process positive regulation of vasoconstrictionIBA:GO_Central1 Publication
Biological Process response to ethanolIEA:Ensembl
Biological Process response to nutrientIEA:Ensembl
Biological Process response to testosteroneIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process second-messenger-mediated signalingIEA:Ensembl
Biological Process smooth muscle contractionIEA:Ensembl
Cellular Location
Cell membrane
Involvement in disease
Bleeding disorder, platelet-type, 13 (BDPLT13):
A disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding.
Topology
Extracellular: 1-29
Helical: 30-52
Cytoplasmic: 53-66
Helical: 67-87
Extracellular: 88-106
Helical: 107-128
Cytoplasmic: 129-149
Helical: 150-172
Extracellular: 173-193
Helical: 194-219
Cytoplasmic: 220-246
Helical: 247-270
Extracellular: 271-289
Helical: 290-311
Cytoplasmic: 312-343
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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