Mouse Anti-TBXA2R Recombinant Antibody (CBYJT-2176) (CBMAB-T1281-YJ)

Name: Mouse Anti-TBXA2R Recombinant Antibody (CBYJT-2176)
SKU: CBMAB-T1281-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-2176

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Thromboxane A2 Receptor

Introduction

TBXA2R is a member of the G protein-coupled receptor family. TBXA2R interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in TBXA2R results in a bleeding disorder.

Entrez Gene ID

6915

UniProt ID

P21731

Alternative Names

Thromboxane A2 Receptor; Prostanoid TP Receptor; TXA2-R; BDPLT13

Function

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C.
Isoform 1
Activates adenylyl cyclase.
Isoform 2
Inhibits adenylyl cyclase.

Biological Process

Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayIBA:GO_Central1 Publication
Biological Process cellular response to lipopolysaccharideIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathwayTAS:ProtInc1 Publication
Biological Process inflammatory responseIBA:GO_Central1 Publication
Biological Process negative regulation of cell migration involved in sprouting angiogenesisIGI:BHF-UCL1 Publication
Biological Process positive regulation of angiogenesisIEA:Ensembl
Biological Process positive regulation of blood coagulationIEA:Ensembl
Biological Process positive regulation of blood pressureIBA:GO_Central1 Publication
Biological Process positive regulation of cytosolic calcium ion concentrationIBA:GO_Central1 Publication
Biological Process positive regulation of smooth muscle contractionIEA:Ensembl
Biological Process positive regulation of vasoconstrictionIBA:GO_Central1 Publication
Biological Process response to ethanolIEA:Ensembl
Biological Process response to nutrientIEA:Ensembl
Biological Process response to testosteroneIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process second-messenger-mediated signalingIEA:Ensembl
Biological Process smooth muscle contractionIEA:Ensembl

Cellular Location

Cell membrane

Involvement in disease

Bleeding disorder, platelet-type, 13 (BDPLT13):
A disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding.

Topology

Extracellular: 1-29
Helical: 30-52
Cytoplasmic: 53-66
Helical: 67-87
Extracellular: 88-106
Helical: 107-128
Cytoplasmic: 129-149
Helical: 150-172
Extracellular: 173-193
Helical: 194-219
Cytoplasmic: 220-246
Helical: 247-270
Extracellular: 271-289
Helical: 290-311
Cytoplasmic: 312-343

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TBXA2R Recombinant Antibody (CBYJT-2177) (CAT#: CBMAB-T1282-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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