TCF7L2

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

TCF7L2 Gene(Protein Coding) Transcription Factor 7 Like 2

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.

Biological Process blood vessel developmentIMP:BHF-UCL1 Publication
Biological Process canonical Wnt signaling pathwayIBA:GO_Central1 Publication
Biological Process canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transitionIMP:BHF-UCL1 Publication
Biological Process fat cell differentiationIDA:BHF-UCL1 Publication
Biological Process glucose homeostasisIDA:BHF-UCL1 Publication
Biological Process maintenance of DNA repeat elementsIMP:BHF-UCL1 Publication
Biological Process myoblast fate commitmentIDA:BHF-UCL1 Publication
Biological Process negative regulation of canonical Wnt signaling pathwayIMP:UniProtKB1 Publication
Biological Process negative regulation of DNA-binding transcription factor activityIDA:BHF-UCL1 Publication
Biological Process negative regulation of DNA-templated transcriptionIDA:BHF-UCL2 Publications
Biological Process negative regulation of extrinsic apoptotic signaling pathwayISS:BHF-UCL
Biological Process negative regulation of transcription by RNA polymerase IIIDA:BHF-UCL1 Publication
Biological Process negative regulation of type B pancreatic cell apoptotic processISS:BHF-UCL
Biological Process pancreas developmentTAS:BHF-UCL1 Publication
Biological Process positive regulation of epithelial cell proliferationIMP:BHF-UCL1 Publication
Biological Process positive regulation of heparan sulfate proteoglycan biosynthetic processIMP:BHF-UCL1 Publication
Biological Process positive regulation of insulin secretionIMP:BHF-UCL1 Publication
Biological Process positive regulation of protein bindingIDA:BHF-UCL1 Publication
Biological Process positive regulation of protein export from nucleusIMP:BHF-UCL1 Publication
Biological Process positive regulation of protein kinase B signalingIMP:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIDA:BHF-UCL2 Publications
Biological Process regulation of hormone metabolic processIDA:BHF-UCL1 Publication
Biological Process regulation of smooth muscle cell proliferationIMP:BHF-UCL1 Publication
Biological Process regulation of transcription by RNA polymerase IIIDA:BHF-UCL1 Publication
Biological Process response to glucoseISS:BHF-UCLBy Similarity

Nucleus, PML body
Nucleus
Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies.

Diabetes mellitus, non-insulin-dependent (NIDDM):
A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.