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Rabbit Anti-TCF4 Recombinant Antibody (CBYJT-2272) (CBMAB-T1381-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to TCF4 (Transcription Factor 4). The antibody can be used for immunoassay techniques, such as WB, IP, ChIP.
See all TCF7L2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBYJT-2272
Antibody Isotype
IgG
Application
WB, IP, ChIP

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Antibody
Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
transcription factor 4
Introduction
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.
Entrez Gene ID
Human6925
Mouse21413
Rat84382
UniProt ID
HumanP15884
MouseQ60722
RatQ62655
Alternative Names
TCF4; TCF-4
Function
Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity).
Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.
Biological Process
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process nervous system developmentIEA:UniProtKB-KW
Biological Process positive regulation of DNA-templated transcriptionIDA:UniProtKB2 Publications
Biological Process positive regulation of neuron differentiationISS:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIISS:BHF-UCLBy Similarity
Biological Process protein-DNA complex assemblyISS:BHF-UCLBy Similarity
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Cellular Location
Nucleus
Involvement in disease
Pitt-Hopkins syndrome (PTHS):
A syndrome characterized by intellectual disability, wide mouth and distinctive facial features, and intermittent hyperventilation followed by apnea. Features include intellectual disability with severe speech impairment, normal growth parameters at birth, postnatal microcephaly, breathing anomalies, severe motor developmental delay, motor incoordination, ocular anomalies, constipation, seizures, typical behavior and subtle brain abnormalities.
Corneal dystrophy, Fuchs endothelial, 3 (FECD3):
A late-onset form of Fuchs endothelial corneal dystrophy, a disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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