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Mouse Anti-TCF7L2 Recombinant Antibody (1A1) (CBMAB-A8963-LY)

The product is antibody recognizes TCF7L2. The antibody 1A1 immunoassay techniques such as: WB, ELISA.
See all TCF7L2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A1
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
TCF7L2 (AAH32656, 1 a.a. ~ 455 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TCF7L2 Gene(Protein Coding) Transcription Factor 7 Like 2
Introduction
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes
Entrez Gene ID
6934
UniProt ID
Q9NQB0
Alternative Names
TCF-4; TCF4
Function
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
Biological Process
Biological Process blood vessel developmentIMP:BHF-UCL1 Publication
Biological Process canonical Wnt signaling pathwayIBA:GO_Central1 Publication
Biological Process canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transitionIMP:BHF-UCL1 Publication
Biological Process fat cell differentiationIDA:BHF-UCL1 Publication
Biological Process glucose homeostasisIDA:BHF-UCL1 Publication
Biological Process maintenance of DNA repeat elementsIMP:BHF-UCL1 Publication
Biological Process myoblast fate commitmentIDA:BHF-UCL1 Publication
Biological Process negative regulation of canonical Wnt signaling pathwayIMP:UniProtKB1 Publication
Biological Process negative regulation of DNA-binding transcription factor activityIDA:BHF-UCL1 Publication
Biological Process negative regulation of DNA-templated transcriptionIDA:BHF-UCL2 Publications
Biological Process negative regulation of extrinsic apoptotic signaling pathwayISS:BHF-UCL
Biological Process negative regulation of transcription by RNA polymerase IIIDA:BHF-UCL1 Publication
Biological Process negative regulation of type B pancreatic cell apoptotic processISS:BHF-UCL
Biological Process pancreas developmentTAS:BHF-UCL1 Publication
Biological Process positive regulation of epithelial cell proliferationIMP:BHF-UCL1 Publication
Biological Process positive regulation of heparan sulfate proteoglycan biosynthetic processIMP:BHF-UCL1 Publication
Biological Process positive regulation of insulin secretionIMP:BHF-UCL1 Publication
Biological Process positive regulation of protein bindingIDA:BHF-UCL1 Publication
Biological Process positive regulation of protein export from nucleusIMP:BHF-UCL1 Publication
Biological Process positive regulation of protein kinase B signalingIMP:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase IIIDA:BHF-UCL2 Publications
Biological Process regulation of hormone metabolic processIDA:BHF-UCL1 Publication
Biological Process regulation of smooth muscle cell proliferationIMP:BHF-UCL1 Publication
Biological Process regulation of transcription by RNA polymerase IIIDA:BHF-UCL1 Publication
Biological Process response to glucoseISS:BHF-UCLBy Similarity
Cellular Location
Nucleus, PML body
Nucleus
Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies.
Involvement in disease
Diabetes mellitus, non-insulin-dependent (NIDDM):
A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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