TGFB2

TGFB2 has suppressive effects on interleukin-2 dependent T-cell growth. activation of protein kinase activity, BMP signaling pathway, cardiac epithelial to mesenchymal transition, cardiac muscle cell proliferation.

Transforming Growth Factor Beta 2

Transforming growth factor beta-2 proprotein
Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
Latency-associated peptide
Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix (By similarity).
Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 (By similarity).
Transforming growth factor beta-2
Multifunctional protein that regulates various processes such as angiogenesis and heart development (PubMed:22772371, PubMed:22772368).
Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity).
At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity).
Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity).

Biological Process activation of protein kinase activitySource:BHF-UCL2 Publications
Biological Process ascending aorta morphogenesisSource:BHF-UCL
Biological Process atrial septum morphogenesisSource:BHF-UCL
Biological Process atrial septum primum morphogenesisSource:BHF-UCL
Biological Process atrioventricular valve morphogenesisSource:BHF-UCL
Biological Process BMP signaling pathwaySource:GO_Central1 Publication
Biological Process cardiac epithelial to mesenchymal transitionSource:BHF-UCL1 Publication
Biological Process cardiac muscle cell proliferationSource:UniProtKB1 Publication
Biological Process cardiac right ventricle morphogenesisSource:BHF-UCL
Biological Process cardioblast differentiationSource:UniProtKB1 Publication
Biological Process cell deathSource:UniProtKB1 Publication
Biological Process cell migrationSource:BHF-UCL1 Publication
Biological Process cell morphogenesisSource:UniProtKB1 Publication
Biological Process cell-cell junction organizationSource:BHF-UCL1 Publication
Biological Process collagen fibril organizationSource:BHF-UCL1 Publication
Biological Process cranial skeletal system developmentSource:BHF-UCL
Biological Process dopamine biosynthetic processSource:UniProtKB
Biological Process embryo development ending in birth or egg hatchingSource:UniProtKB1 Publication
Biological Process embryonic digestive tract developmentSource:DFLAT1 Publication
Biological Process embryonic limb morphogenesisSource:BHF-UCL
Biological Process endocardial cushion fusionSource:BHF-UCL
Biological Process endocardial cushion morphogenesisSource:BHF-UCL
Biological Process epithelial to mesenchymal transitionSource:BHF-UCL2 Publications
Biological Process extrinsic apoptotic signaling pathwaySource:BHF-UCL1 Publication
Biological Process eye developmentSource:UniProtKB1 Publication
Biological Process generation of neuronsSource:UniProtKB1 Publication
Biological Process glial cell migrationSource:BHF-UCL1 Publication
Biological Process hair follicle developmentSource:UniProtKB1 Publication
Biological Process hair follicle morphogenesisSource:UniProtKB
Biological Process heart developmentSource:UniProtKB1 Publication
Biological Process heart morphogenesisSource:BHF-UCL1 Publication
Biological Process heart valve morphogenesisSource:BHF-UCL
Biological Process hemopoiesisSource:UniProtKB
Biological Process inner ear developmentSource:BHF-UCL
Biological Process kidney developmentSource:BHF-UCL
Biological Process male gonad developmentSource:BHF-UCL
Biological Process membranous septum morphogenesisSource:BHF-UCL
Biological Process negative regulation of alkaline phosphatase activitySource:BHF-UCL1 Publication
Biological Process negative regulation of angiogenesisSource:BHF-UCL2 Publications
Biological Process negative regulation of cell growthSource:BHF-UCL1 Publication
Biological Process negative regulation of cell population proliferationSource:UniProtKB1 Publication
Biological Process negative regulation of epithelial cell proliferationSource:BHF-UCL1 Publication
Biological Process negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formationSource:BHF-UCL
Biological Process negative regulation of gene expressionSource:BHF-UCL1 Publication
Biological Process negative regulation of macrophage cytokine productionSource:DFLAT1 Publication
Biological Process negative regulation of Ras protein signal transductionSource:BHF-UCL
Biological Process neural retina developmentSource:BHF-UCL
Biological Process neural tube closureSource:BHF-UCL
Biological Process neuron developmentSource:UniProtKB
Biological Process neutrophil chemotaxisSource:UniProtKB
Biological Process odontogenesisSource:BHF-UCL1 Publication
Biological Process outflow tract septum morphogenesisSource:BHF-UCL
Biological Process pathway-restricted SMAD protein phosphorylationSource:BHF-UCL2 Publications
Biological Process pharyngeal arch artery morphogenesisSource:BHF-UCL
Biological Process positive regulation of cardioblast differentiationSource:UniProtKB1 Publication
Biological Process positive regulation of cell adhesion mediated by integrinSource:BHF-UCL2 Publications
Biological Process positive regulation of cell cycleSource:UniProtKB
Biological Process positive regulation of cell divisionSource:UniProtKB-KW
Biological Process positive regulation of cell growthSource:UniProtKB2 Publications
Biological Process positive regulation of cell population proliferationSource:UniProtKB1 Publication
Biological Process positive regulation of epithelial cell migrationSource:BHF-UCL1 Publication
Biological Process positive regulation of epithelial to mesenchymal transitionSource:BHF-UCL2 Publications
Biological Process positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formationSource:BHF-UCL
Biological Process positive regulation of heart contractionSource:UniProtKB1 Publication
Biological Process positive regulation of immune responseSource:UniProtKB
Biological Process positive regulation of integrin biosynthetic processSource:BHF-UCL1 Publication
Biological Process positive regulation of miRNA transcriptionSource:BHF-UCL1 Publication
Biological Process positive regulation of neuron apoptotic processSource:UniProtKB1 Publication
Biological Process positive regulation of Notch signaling pathwaySource:BHF-UCL1 Publication
Biological Process positive regulation of ossificationSource:BHF-UCL1 Publication
Biological Process positive regulation of pathway-restricted SMAD protein phosphorylationSource:ComplexPortal1 Publication
Biological Process positive regulation of phosphatidylinositol 3-kinase signalingSource:BHF-UCL1 Publication
Biological Process positive regulation of protein secretionSource:BHF-UCL1 Publication
Biological Process positive regulation of stress-activated MAPK cascadeSource:BHF-UCL1 Publication
Biological Process positive regulation of timing of catagenSource:UniProtKB1 Publication
Biological Process protein phosphorylationSource:BHF-UCL1 Publication
Biological Process pulmonary valve morphogenesisSource:BHF-UCL
Biological Process regulation of apoptotic process involved in outflow tract morphogenesisSource:BHF-UCL
Biological Process regulation of cell population proliferationSource:BHF-UCL1 Publication
Biological Process regulation of timing of catagenSource:UniProtKB1 Publication
Biological Process regulation of transforming growth factor beta2 productionSource:BHF-UCL1 Publication
Biological Process response to hypoxiaSource:BHF-UCL1 Publication
Biological Process response to progesteroneSource:BHF-UCL1 Publication
Biological Process response to woundingSource:BHF-UCL2 Publications
Biological Process response to xenobiotic stimulusSource:UniProtKB1 Publication
Biological Process salivary gland morphogenesisSource:BHF-UCL1 Publication
Biological Process secondary palate developmentSource:BHF-UCL
Biological Process skeletal system developmentSource:BHF-UCL
Biological Process SMAD protein signal transductionSource:BHF-UCL1 Publication
Biological Process somatic stem cell divisionSource:UniProtKB
Biological Process substantia propria of cornea developmentSource:BHF-UCL
Biological Process transforming growth factor beta receptor signaling pathwaySource:BHF-UCL2 Publications
Biological Process uterine wall breakdownSource:BHF-UCL1 Publication
Biological Process uterus developmentSource:BHF-UCL
Biological Process ventricular septum morphogenesisSource:BHF-UCL
Biological Process ventricular trabecula myocardium morphogenesisSource:BHF-UCL
Biological Process wound healingSource:UniProtKB

Latency-associated peptide
Secreted, extracellular space, extracellular matrix
Transforming growth factor beta-2
Secreted

Loeys-Dietz syndrome 4 (LDS4):
An aortic aneurysm syndrome with widespread systemic involvement. LDS4 is characterized by arterial tortuosity, aortic dissection, intracranial aneurysm and subarachnoid hemorrhage, hypertelorism, bifid uvula, pectus deformity, bicuspid aortic valve, arachnodactyly, scoliosis, foot deformities, dural ectasia, joint hyperflexibility, and thin skin with easy bruising and striae.

Transforming growth factor beta-2 proprotein
The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-2 (TGF-beta-2) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-2 inactive.