THOP1

The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]
Full Name
THOP1 Gene(Protein Coding) Thimet Oligopeptidase 1
Function
Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:7639763, PubMed:17251185).
Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:7639763, PubMed:17251185).
Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity).
Biological Process
Biological Process peptide metabolic processSource:GO_Central1 Publication
Biological Process protein polyubiquitinationSource:Reactome
Biological Process proteolysisSource:GO_Central1 Publication
Cellular Location
Cytoplasm
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Anti-THOP1 antibodies

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Mouse Anti-THOP1 Recombinant Antibody (IVD6) (CBMAB-CP3220-LY)

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Target: THOP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey
Clone: IVD6
Application*: WB, P
Datasheet SDS

Mouse Anti-Thop1 Recombinant Antibody (CBYJT-3016) (CBMAB-T2266-YJ)

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Target: THOP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: CBYJT-3016
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-THOP1 Recombinant Antibody (CBYJT-3014) (CBMAB-T2264-YJ)

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Target: THOP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Rabbit
Clone: CBYJT-3014
Application*: WB, IH, IC, IF, P
Datasheet SDS

Mouse Anti-THOP1 Recombinant Antibody (CBYJT-3013) (CBMAB-T2263-YJ)

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Target: THOP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3013
Application*: IC, WB
Datasheet SDS

Mouse Anti-THOP1 Recombinant Antibody (CBYJT-3012) (CBMAB-T2262-YJ)

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Target: THOP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3012
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-THOP1 Recombinant Antibody (CBYJT-3011) (CBMAB-T2261-YJ)

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Target: THOP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3011
Application*: IC, WB
Datasheet SDS

Mouse Anti-THOP1 Recombinant Antibody (CBYJT-3010) (CBMAB-T2260-YJ)

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Target: THOP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3010
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-THOP1 Recombinant Antibody (CBYJT-3009) (CBMAB-T2259-YJ)

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Target: THOP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3009
Application*: WB, IP
Datasheet SDS

Mouse Anti-THOP1 Recombinant Antibody (CBYJT-3008) (CBMAB-T2258-YJ)

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Target: THOP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3008
Application*: IH, P, WB
Datasheet SDS

Mouse Anti-THOP1 Recombinant Antibody (CBYJT-3007) (CBMAB-T2257-YJ)

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Target: THOP1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBYJT-3007
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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