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THOP1

The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]
Full Name
THOP1 Gene(Protein Coding) Thimet Oligopeptidase 1
Function
Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:7639763, PubMed:17251185).
Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:7639763, PubMed:17251185).
Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity).
Biological Process
Biological Process peptide metabolic processSource:GO_Central1 Publication
Biological Process protein polyubiquitinationSource:Reactome
Biological Process proteolysisSource:GO_Central1 Publication
Cellular Location
Cytoplasm

Anti-THOP1 antibodies

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Target: THOP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3010
Application*: E, IP, WB
Target: THOP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3011
Application*: IC, WB
Target: THOP1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBYJT-3007
Application*: E, WB
Target: THOP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3008
Application*: IH, P, WB
Target: THOP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3009
Application*: WB, IP
Target: THOP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3012
Application*: E, IP, WB
Target: THOP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3013
Application*: IC, WB
Target: THOP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Rabbit
Clone: CBYJT-3014
Application*: WB, IH, IC, IF, P
Target: THOP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: CBYJT-3016
Application*: WB, IP, IF, E
Target: THOP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EPR7651
Application*: IC, IF, WB
Target: THOP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey
Clone: IVD6
Application*: WB, P
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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