Sign in or Register   Sign in or Register
  |  

Mouse Anti-THOP1 Recombinant Antibody (CBYJT-3007) (CBMAB-T2257-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to THOP1 (Thimet Oligopeptidase 1). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all THOP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3007
Antibody Isotype
IgM, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa255-355 from human THOP1 with GST tag
Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Ascites
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 255-355

Target

Full Name
THOP1 Gene(Protein Coding) Thimet Oligopeptidase 1
Introduction
THOP1 is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. THOP1 also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides.
Entrez Gene ID
7064
UniProt ID
P52888
Alternative Names
Thimet Oligopeptidase 1; Endopeptidase 24.15; EC 3.4.24.15; MP78; Thimet Oligopeptidase; MEPD_HUMAN; EC 3.4.24; EP24.15; TOP
Function
Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:7639763, PubMed:17251185).
Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:7639763, PubMed:17251185).
Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity).
Biological Process
Biological Process peptide metabolic processSource:GO_Central1 Publication
Biological Process protein polyubiquitinationSource:Reactome
Biological Process proteolysisSource:GO_Central1 Publication
Cellular Location
Cytoplasm
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-THOP1 Recombinant Antibody (CBYJT-3007)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare