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Mouse Anti-THOP1 Recombinant Antibody (IVD6) (CBMAB-CP3220-LY)

The product is antibody recognizes THOP1. The antibody IVD6 immunoassay techniques such as: WB,IHC-P.
See all THOP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Monkey
Clone
IVD6
Antibody Isotype
IgG2b
Application
WB, IHC-P

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues in the amino-terminal region of Thimet oligopeptidase protein.
Specificity
Human, Monkey
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
THOP1 Gene(Protein Coding) Thimet Oligopeptidase 1
Introduction
The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]
Entrez Gene ID
Human7064
Monkey721578
UniProt ID
HumanP52888
MonkeyI0FUN0
Alternative Names
Thimet Oligopeptidase 1; Endopeptidase 24.15; EC 3.4.24.15; MP78; Thimet Oligopeptidase; MEPD_HUMAN; EC 3.4.24; EP24.15; TOP;
Function
Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:7639763, PubMed:17251185).
Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:7639763, PubMed:17251185).
Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity).
Biological Process
Biological Process peptide metabolic processSource:GO_Central1 Publication
Biological Process protein polyubiquitinationSource:Reactome
Biological Process proteolysisSource:GO_Central1 Publication
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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