TMEM119

TMEM119 (Transmembrane Protein 119) is a Protein Coding gene.

Full Name

transmembrane protein 119

Function

Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746).
May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).

Biological Process

Biological Process biomineral tissue developmentSource:UniProtKB-KW
Biological Process endochondral ossificationSource:ARUK-UCL
Biological Process negative regulation of bone resorptionSource:ARUK-UCL
Biological Process negative regulation of myotube differentiationSource:ARUK-UCL
Biological Process osteoblast differentiationSource:Ensembl
Biological Process positive regulation of bone developmentSource:UniProtKB
Biological Process positive regulation of bone mineralizationSource:UniProtKB1 Publication
Biological Process positive regulation of gene expressionSource:ARUK-UCL
Biological Process positive regulation of osteoblast differentiationSource:UniProtKB1 Publication
Biological Process positive regulation of osteoblast proliferationSource:UniProtKB1 Publication
Biological Process positive regulation of protein phosphorylationSource:ARUK-UCL
Biological Process spermatid differentiationSource:UniProtKB
Biological Process spermatogenesisSource:UniProtKB

Cellular Location

Cell membrane
Cytoplasm
Endoplasmic reticulum membrane

Topology

Extracellular: 26-96
Helical: 97-117
Cytoplasmic: 118-283