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Mouse Anti-TMEM119 Recombinant Antibody (CBT3224) (V2LY-0625-LY1893)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3224
Antibody Isotype
IgG2a
Application
IHC, FC

Basic Information

Immunogen
Purified recombinant fragment of human TMEM119 (AA: 118-283) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
transmembrane protein 119
Entrez Gene ID
338773
Function
Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746).
May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).
Biological Process
Biological Process biomineral tissue developmentSource:UniProtKB-KW
Biological Process endochondral ossificationSource:ARUK-UCL
Biological Process negative regulation of bone resorptionSource:ARUK-UCL
Biological Process negative regulation of myotube differentiationSource:ARUK-UCL
Biological Process osteoblast differentiationSource:Ensembl
Biological Process positive regulation of bone developmentSource:UniProtKB
Biological Process positive regulation of bone mineralizationSource:UniProtKB1 Publication
Biological Process positive regulation of gene expressionSource:ARUK-UCL
Biological Process positive regulation of osteoblast differentiationSource:UniProtKB1 Publication
Biological Process positive regulation of osteoblast proliferationSource:UniProtKB1 Publication
Biological Process positive regulation of protein phosphorylationSource:ARUK-UCL
Biological Process spermatid differentiationSource:UniProtKB
Biological Process spermatogenesisSource:UniProtKB
Cellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum membrane
Topology
Extracellular: 26-96
Helical: 97-117
Cytoplasmic: 118-283
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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