Human TMEM119 ELISA Kit (V2LY-0626-LY5361)

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Tested Data
Request for COA
Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0092 ng/mL
Detection Range
0.02-7 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
29.2 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
transmembrane protein 119
Function
Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746).
May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).
Biological Process
Biological Process biomineral tissue developmentSource:UniProtKB-KW
Biological Process endochondral ossificationSource:ARUK-UCL
Biological Process negative regulation of bone resorptionSource:ARUK-UCL
Biological Process negative regulation of myotube differentiationSource:ARUK-UCL
Biological Process osteoblast differentiationSource:Ensembl
Biological Process positive regulation of bone developmentSource:UniProtKB
Biological Process positive regulation of bone mineralizationSource:UniProtKB1 Publication
Biological Process positive regulation of gene expressionSource:ARUK-UCL
Biological Process positive regulation of osteoblast differentiationSource:UniProtKB1 Publication
Biological Process positive regulation of osteoblast proliferationSource:UniProtKB1 Publication
Biological Process positive regulation of protein phosphorylationSource:ARUK-UCL
Biological Process spermatid differentiationSource:UniProtKB
Biological Process spermatogenesisSource:UniProtKB
Cellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum membrane
Topology
Extracellular: 26-96
Helical: 97-117
Cytoplasmic: 118-283
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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