TNC

This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]
Full Name
TNC Gene(Protein Coding) Tenascin C
Function
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).
Biological Process
Biological Process cell adhesionSource:ProtInc1 Publication
Biological Process mesenchymal-epithelial cell signaling involved in prostate gland developmentSource:Ensembl
Biological Process neuromuscular junction developmentSource:Ensembl
Biological Process neuron projection developmentSource:GO_Central1 Publication
Biological Process osteoblast differentiationSource:UniProtKB1 Publication
Biological Process peripheral nervous system axon regenerationSource:Ensembl
Biological Process positive regulation of cell population proliferationSource:Ensembl
Biological Process positive regulation of gene expressionSource:Ensembl
Biological Process prostate gland epithelium morphogenesisSource:Ensembl
Biological Process regulation of cell adhesionSource:ComplexPortal1 Publication
Biological Process regulation of cell growthSource:ComplexPortal1 Publication
Biological Process regulation of cell migrationSource:ComplexPortal1 Publication
Biological Process regulation of inflammatory responseSource:Ensembl
Biological Process response to woundingSource:ComplexPortal1 Publication
Cellular Location
Secreted, extracellular space, extracellular matrix
Involvement in disease
Deafness, autosomal dominant, 56 (DFNA56):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA56 is characterized by progressive hearing impairment with postlingual onset.
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Anti-TNC antibodies

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Mouse Anti-TNC Recombinant Antibody (CBYJT-3597) (CBMAB-T2927-YJ)

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Target: TNC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3597
Application*: IC, IH
Datasheet SDS

Mouse Anti-TNC Recombinant Antibody (T20) (CBMAB-AO1021LY)

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Target: TNC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: T20
Application*: ELISA, WB, IHC, ICC
Datasheet SDS

Rabbit Anti-TNC Recombinant Antibody (D16C4) (CBMAB-CP2733-LY)

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Target: TNC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D16C4
Application*: WB, IP
Datasheet SDS

Mouse Anti-TNC Recombinant Antibody (3B4) (CBMAB-A9230-LY)

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Target: TNC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B4
Application*: WB, E
Datasheet SDS

Rabbit Anti-TNC Recombinant Antibody (CBYJT-3601) (CBMAB-T2933-YJ)

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Target: TNC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYJT-3601
Application*: WB, IP
Datasheet SDS

Mouse Anti-TNC Recombinant Antibody (4C8MS) (CBMAB-T2931-YJ)

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Target: TNC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 4C8MS
Application*: WB, F, E, IH, IC, IF, P, C, MC
Datasheet SDS

Mouse Anti-TNC Recombinant Antibody (CBYJT-3599) (CBMAB-T2929-YJ)

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Target: TNC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3599
Application*: F, P, IF, MC
Datasheet SDS

Mouse Anti-TNC Recombinant Antibody (CBYJT-3598) (CBMAB-T2928-YJ)

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Target: TNC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3598
Application*: WB, P, C
Datasheet SDS

Mouse Anti-TNC Recombinant Antibody (CBYJT-3596) (CBMAB-T2924-YJ)

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Target: TNC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3596
Application*: DB, E, IC, IF, C, P, R, WB
Datasheet SDS

Mouse Anti-TNC Recombinant Antibody (CBYJT-3595) (CBMAB-T2923-YJ)

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Target: TNC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3595
Application*: E, WB
Datasheet SDS

Rat Anti-TNC Recombinant Antibody (CBYJT-3594) (CBMAB-T2922-YJ)

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Target: TNC
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3594
Application*: WB
Datasheet SDS

Rat Anti-TNC Recombinant Antibody (CBYJT-3593) (CBMAB-T2921-YJ)

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Target: TNC
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3593
Application*: IC
Datasheet SDS

Rat Anti-Tnc Recombinant Antibody (CBYJT-3603) (CBMAB-T2935-YJ)

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Target: TNC
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse, Rabbit
Clone: CBYJT-3603
Application*: DB, E, IC, IF, C, IP, WB
Datasheet SDS

Rat Anti-Tnc Recombinant Antibody (CBYJT-3602) (CBMAB-T2934-YJ)

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Target: TNC
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Human
Clone: CBYJT-3602
Application*: WB, N, IC
Datasheet SDS

Mouse Anti-TNC Recombinant Antibody (DB7) (CBMAB-0884CQ)

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Target: TNC
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: DB7
Application*: IF, P, IP, WB
Datasheet SDS

Mouse Anti-TNC Recombinant Antibody (SPM319) (CBMAB-0883CQ)

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Target: TNC
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SPM319
Application*: P
Datasheet SDS

Mouse Anti-TNC Recombinant Antibody (BC-24) (CBMAB-0882CQ)

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Target: TNC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BC-24
Application*: DB, E, IC, IF, IH, R, WB
Datasheet SDS

Mouse Anti-TNC Recombinant Antibody (T2H5) (CBMAB-0881CQ)

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Target: TNC
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: T2H5
Application*: IF, P, IP, WB
Datasheet SDS

Rabbit Anti-TNC Recombinant Antibody (BA0263) (CBMAB-0880CQ)

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Target: TNC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0263
Application*: F, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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