TNC

This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

TNC Gene(Protein Coding) Tenascin C

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).

Biological Process cell adhesionSource:ProtInc1 Publication
Biological Process mesenchymal-epithelial cell signaling involved in prostate gland developmentSource:Ensembl
Biological Process neuromuscular junction developmentSource:Ensembl
Biological Process neuron projection developmentSource:GO_Central1 Publication
Biological Process osteoblast differentiationSource:UniProtKB1 Publication
Biological Process peripheral nervous system axon regenerationSource:Ensembl
Biological Process positive regulation of cell population proliferationSource:Ensembl
Biological Process positive regulation of gene expressionSource:Ensembl
Biological Process prostate gland epithelium morphogenesisSource:Ensembl
Biological Process regulation of cell adhesionSource:ComplexPortal1 Publication
Biological Process regulation of cell growthSource:ComplexPortal1 Publication
Biological Process regulation of cell migrationSource:ComplexPortal1 Publication
Biological Process regulation of inflammatory responseSource:Ensembl
Biological Process response to woundingSource:ComplexPortal1 Publication

Secreted, extracellular space, extracellular matrix

Deafness, autosomal dominant, 56 (DFNA56):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA56 is characterized by progressive hearing impairment with postlingual onset.