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Rat Anti-Tnc Recombinant Antibody (CBYJT-3602) (CBMAB-T2934-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Tnc (Tenascin C). The antibody can be used for immunoassay techniques, such as WB, Neut, ICC.
See all Tnc antibodies

Summary

Host Animal
Rat
Specificity
Mouse, Human
Clone
CBYJT-3602
Antibody Isotype
IgG2a
Application
WB, Neut, ICC

Basic Information

Immunogen
Mouse immature astrocyte-derived Tenascin C
Specificity
Mouse, Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNC Gene(Protein Coding) Tenascin C
Introduction
Tnc is an Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. It promotes neurite outgrowth when provided to neurons in culture. Tnc may function in supporting the growth of epithelial tumors. It is a ligand for integrins ITGA8:ITGB1, ITGA9:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. In tumors, it stimulates angiogenesis by elongation, migration and sprouting of endothelial cells.
Entrez Gene ID
Human3371
Mouse21923
UniProt ID
HumanO15417
MouseQ80WC3
Alternative Names
TN; Hxb; Ten; TN-C; AI528729; cytotactin; tenascin-C; C130033P17Rik
Function
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).
Biological Process
Biological Process cell adhesionSource:ProtInc1 Publication
Biological Process mesenchymal-epithelial cell signaling involved in prostate gland developmentSource:Ensembl
Biological Process neuromuscular junction developmentSource:Ensembl
Biological Process neuron projection developmentSource:GO_Central1 Publication
Biological Process osteoblast differentiationSource:UniProtKB1 Publication
Biological Process peripheral nervous system axon regenerationSource:Ensembl
Biological Process positive regulation of cell population proliferationSource:Ensembl
Biological Process positive regulation of gene expressionSource:Ensembl
Biological Process prostate gland epithelium morphogenesisSource:Ensembl
Biological Process regulation of cell adhesionSource:ComplexPortal1 Publication
Biological Process regulation of cell growthSource:ComplexPortal1 Publication
Biological Process regulation of cell migrationSource:ComplexPortal1 Publication
Biological Process regulation of inflammatory responseSource:Ensembl
Biological Process response to woundingSource:ComplexPortal1 Publication
Cellular Location
Secreted, extracellular space, extracellular matrix
Involvement in disease
Deafness, autosomal dominant, 56 (DFNA56):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA56 is characterized by progressive hearing impairment with postlingual onset.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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