Mouse Anti-TNC Recombinant Antibody (T2H5) (CBMAB-0881CQ)

Name: Mouse Anti-TNC Recombinant Antibody (T2H5)
SKU: CBMAB-0881CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

T2H5

Application

IF, IHC-P, IP, WB

Immunogen

Full length native protein

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TNC Gene(Protein Coding) Tenascin C

Introduction

This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).

Entrez Gene ID

3371

UniProt ID

P24821

Alternative Names

GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225

Function

Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).

Biological Process

Biological Process cell adhesionSource:ProtInc1 Publication
Biological Process mesenchymal-epithelial cell signaling involved in prostate gland developmentSource:Ensembl
Biological Process neuromuscular junction developmentSource:Ensembl
Biological Process neuron projection developmentSource:GO_Central1 Publication
Biological Process osteoblast differentiationSource:UniProtKB1 Publication
Biological Process peripheral nervous system axon regenerationSource:Ensembl
Biological Process positive regulation of cell population proliferationSource:Ensembl
Biological Process positive regulation of gene expressionSource:Ensembl
Biological Process prostate gland epithelium morphogenesisSource:Ensembl
Biological Process regulation of cell adhesionSource:ComplexPortal1 Publication
Biological Process regulation of cell growthSource:ComplexPortal1 Publication
Biological Process regulation of cell migrationSource:ComplexPortal1 Publication
Biological Process regulation of inflammatory responseSource:Ensembl
Biological Process response to woundingSource:ComplexPortal1 Publication

Cellular Location

Secreted, extracellular space, extracellular matrix

Involvement in disease

Deafness, autosomal dominant, 56 (DFNA56):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA56 is characterized by progressive hearing impairment with postlingual onset.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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