TNFRSF13C
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]
Full Name
TNFRSF13C Gene(Protein Coding) TNF Receptor Superfamily Member 13C
Function
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process B cell costimulation Source:GO_Central1 Publication
Biological Process positive regulation of B cell proliferation Source:GO_Central1 Publication
Biological Process positive regulation of T cell proliferation Source:GO_Central1 Publication
Biological Process T cell costimulation Source:GO_Central1 Publication
Biological Process tumor necrosis factor-mediated signaling pathway Source:InterPro
Biological Process B cell costimulation Source:GO_Central1 Publication
Biological Process positive regulation of B cell proliferation Source:GO_Central1 Publication
Biological Process positive regulation of T cell proliferation Source:GO_Central1 Publication
Biological Process T cell costimulation Source:GO_Central1 Publication
Biological Process tumor necrosis factor-mediated signaling pathway Source:InterPro
Cellular Location
Membrane
Involvement in disease
Immunodeficiency, common variable, 4 (CVID4):
A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Topology
Extracellular: 1-78
Helical: 79-99
Cytoplasmic: 100-184
Helical: 79-99
Cytoplasmic: 100-184
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Anti-TNFRSF13C antibodies
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CompareTarget: Tnfrsf13c
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYJT-3736
Application*: F, FN
Target: Tnfrsf13c
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3735
Application*: E, F
Target: TNFRSF13C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3734
Application*: F
Target: TNFRSF13C
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3733
Application*: F, P, WB
Target: TNFRSF13C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3732
Application*: IH, F
Target: TNFRSF13C
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 8A7
Application*: F, C, WB
Target: TNFRSF13C
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: 7H22-E16
Application*: F
Target: TNFRSF13C
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 10-71
Tag: His Tag
Target: TNFRSF13C
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 10-71
Tag: hFc Tag
Target: TNFRSF13C
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-71
Tag: rFc Tag
Target: TNFRSF13C
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-71
Tag: hFc Tag
Target: TNFRSF13C
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 2-71
Tag: hFc Tag
Target: TNFRSF13C
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 6-71
Tag: His Tag
Target: TNFRSF13C
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 2-71
Tag: hFc & AVI Tag
Target: TNFRSF13C
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT4782
Application*: F
Target: TNFRSF13C
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: CBT4095
Application*: WB, F
Target: TNFRSF13C
Specificity: Human
Target: TNFRSF13C
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBWJC-4523
Application*: F
Target: TNFRSF13C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2436
Application*: F, E
Target: TNFRSF13C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0223
Application*: F, IH
Target: TNFRSF13C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-1849
Application*: IF, P, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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