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Mouse Anti-TNFRSF13C Recombinant Antibody (CBT4782) (V2LY-0625-LY891)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4782
Antibody Isotype
IgG2b
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human CD268 (AA: extra 1-78) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TNFRSF13C Gene(Protein Coding) TNF Receptor Superfamily Member 13C
Entrez Gene ID
115650
Function
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process B cell costimulation Source:GO_Central1 Publication
Biological Process positive regulation of B cell proliferation Source:GO_Central1 Publication
Biological Process positive regulation of T cell proliferation Source:GO_Central1 Publication
Biological Process T cell costimulation Source:GO_Central1 Publication
Biological Process tumor necrosis factor-mediated signaling pathway Source:InterPro
Cellular Location
Membrane
Involvement in disease
Immunodeficiency, common variable, 4 (CVID4):
A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Topology
Extracellular: 1-78
Helical: 79-99
Cytoplasmic: 100-184
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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