TROVE2

TROVE2 (TROVE Domain Family Member 2) is a Protein Coding gene. Diseases related to TROVE2 include Sjogren Syndrome and Heart Block, Congenital. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to TROVE2 include RNA binding and U2 snRNA binding.

TROVE domain family, member 2

RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (PubMed:18056422, PubMed:26382853).
Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammatory cytokine secretion (PubMed:26382853).
Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853).
May play roles in cilia formation and/or maintenance (By similarity).

Biological Process cellular response to interferon-alpha Source:UniProtKB1 Publication
Biological Process cilium assembly Source:Ensembl
Biological Process immune system development Source:Ensembl
Biological Process regulation of gene expression Source:UniProtKB1 Publication
Biological Process response to UV Source:Ensembl
Biological Process smoothened signaling pathway Source:Ensembl
Biological Process transcription by RNA polymerase III Source:ProtInc1 Publication

Cytoplasm
Localized in cytoplasmic mRNP granules containing untranslated mRNAs.