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Mouse Anti-TROVE2 Recombinant Antibody (CBYJT-4891) (CBMAB-T4437-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TROVE2 (TROVE Domain Family Member 2). The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all TROVE2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4891
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa1-101 from human TROVE2 (NP_004591) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-101

Target

Full Name
TROVE domain family, member 2
Introduction
TROVE2 (TROVE Domain Family Member 2) is a Protein Coding gene. Diseases related to TROVE2 include Sjogren Syndrome and Heart Block, Congenital. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to TROVE2 include RNA binding and U2 snRNA binding.
Entrez Gene ID
6738
UniProt ID
P10155
Alternative Names
TROVE Domain Family Member 2; Sjoegren Syndrome Type A Antigen; 0 KDa Ribonucleoprotein Ro; RORNP; SSA2; RO60; Sjogren Syndrome Antigen A2 (60kDa, Ribonucleoprotein Autoantigen SS-A/Ro); Sjogren Syndrome Antigen A2 (60kD, Ribonucleoprotein Autoantigen SS-A/Ro)
Function
RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (PubMed:18056422, PubMed:26382853).
Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammatory cytokine secretion (PubMed:26382853).
Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853).
May play roles in cilia formation and/or maintenance (By similarity).
Biological Process
Biological Process cellular response to interferon-alpha Source:UniProtKB1 Publication
Biological Process cilium assembly Source:Ensembl
Biological Process immune system development Source:Ensembl
Biological Process regulation of gene expression Source:UniProtKB1 Publication
Biological Process response to UV Source:Ensembl
Biological Process smoothened signaling pathway Source:Ensembl
Biological Process transcription by RNA polymerase III Source:ProtInc1 Publication
Cellular Location
Cytoplasm
Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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