TSPAN33

TSPAN33 (Tetraspanin 33) is a Protein Coding gene. Diseases related to TSPAN33 include Intracranial Vasospasm and Basilar Artery Occlusion. Gene Ontology (GO) annotations related to TSPAN33 include enzyme binding. An important paralog of TSPAN33 is TSPAN17.

Full Name

Tetraspanin 33

Function

Plays an important role in normal erythropoiesis (By similarity).
It has a role in the differentiation of erythroid progenitors (By similarity).
Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862, PubMed:30463011).
Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).
Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (PubMed:30463011).

Biological Process

Biological Process pore complex assembly Source:UniProtKB1 Publication
Biological Process protein localization to plasma membrane Source:UniProtKB1 Publication
Biological Process protein maturation Source:UniProtKB1 Publication

Cellular Location

Cell membrane
Cell junction, adherens junction
Cytoplasm
Is localized to zonula adherens by PLEKHA7 by a PDZD11-dependent interaction.

Topology

Cytoplasmic: 1-24
Helical: 25-45
Extracellular: 46-64
Helical: 65-85
Cytoplasmic: 86-96
Helical: 97-117
Extracellular: 118-235
Helical: 236-256
Cytoplasmic: 257-283