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Mouse Anti-TSPAN33 Recombinant Antibody (CBYJT-5077) (CBMAB-T4655-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TSPAN33 (Tetraspanin 33). The antibody can be used for immunoassay techniques, such as FC, CyTOF.
See all TSPAN33 antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5077
Antibody Isotype
IgG2b
Application
FC, CyTOF

Basic Information

Immunogen
NS0 mouse myeloma cell line transfected with human TSPAN33, Met1-Tyr283, Accession # NP_848657
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-283

Target

Full Name
Tetraspanin 33
Introduction
TSPAN33 (Tetraspanin 33) is a Protein Coding gene. Diseases related to TSPAN33 include Intracranial Vasospasm and Basilar Artery Occlusion. Gene Ontology (GO) annotations related to TSPAN33 include enzyme binding. An important paralog of TSPAN33 is TSPAN17.
Entrez Gene ID
UniProt ID
Alternative Names
Tetraspanin 33; Proerythroblast New Membrane; TSPAN-33; Penumbra; PEN; Tetraspanin-33; PEN.; HPen
Function
Plays an important role in normal erythropoiesis (By similarity).
It has a role in the differentiation of erythroid progenitors (By similarity).
Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862, PubMed:30463011).
Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).
Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (PubMed:30463011).
Biological Process
Biological Process pore complex assembly Source:UniProtKB1 Publication
Biological Process protein localization to plasma membrane Source:UniProtKB1 Publication
Biological Process protein maturation Source:UniProtKB1 Publication
Cellular Location
Cell membrane
Cell junction, adherens junction
Cytoplasm
Is localized to zonula adherens by PLEKHA7 by a PDZD11-dependent interaction.
Topology
Cytoplasmic: 1-24
Helical: 25-45
Extracellular: 46-64
Helical: 65-85
Cytoplasmic: 86-96
Helical: 97-117
Extracellular: 118-235
Helical: 236-256
Cytoplasmic: 257-283
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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