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Mouse Anti-TSPAN33 Recombinant Antibody (CBT4622) (V2LY-0625-LY1678)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4622
Antibody Isotype
IgG2b
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human TSPAN33 (AA: Extra(46-64)+Extra(118-235)) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Tetraspanin 33
Entrez Gene ID
340348
Function
Plays an important role in normal erythropoiesis (By similarity).
It has a role in the differentiation of erythroid progenitors (By similarity).
Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862, PubMed:30463011).
Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).
Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (PubMed:30463011).
Biological Process
Biological Process pore complex assembly Source:UniProtKB1 Publication
Biological Process protein localization to plasma membrane Source:UniProtKB1 Publication
Biological Process protein maturation Source:UniProtKB1 Publication
Cellular Location
Cell membrane
Cell junction, adherens junction
Cytoplasm
Is localized to zonula adherens by PLEKHA7 by a PDZD11-dependent interaction.
Topology
Cytoplasmic: 1-24
Helical: 25-45
Extracellular: 46-64
Helical: 65-85
Cytoplasmic: 86-96
Helical: 97-117
Extracellular: 118-235
Helical: 236-256
Cytoplasmic: 257-283
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For research use only. Not intended for any clinical use.

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