TTF1
This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011]
Full Name
TTF1 Transcription Termination Factor 1
Function
Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.
Biological Process
DNA-templated transcription, termination1 PublicationNAS:UniProtKB
Negative regulation of DNA replicationIEA:UniProtKB-KW
Termination of RNA polymerase I transcriptionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of DNA replicationIEA:UniProtKB-KW
Termination of RNA polymerase I transcriptionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Nucleus, nucleolus
Nucleus, nucleolus
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Anti-TTF1 antibodies
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Target: TTF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D2E8
Application*: WB, IF, IF (IC)
Target: TTF1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: IHC414
Application*: P, E, IH
Target: TTF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4036
Application*: IH, IC, F
Target: TTF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4345
Application*: F
Target: TTF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF457
Application*: ELISA, WB, IHC
Target: TTF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP141
Application*: ELISA
Target: TTF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBYJT-5146
Application*: E, WB
Target: TTF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5145
Application*: E, WB, P, IF, IC, F
Target: TTF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5144
Application*: E, WB, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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