TTF1

This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011]
Full Name
TTF1 Transcription Termination Factor 1
Function
Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.
Biological Process
DNA-templated transcription, termination1 PublicationNAS:UniProtKB
Negative regulation of DNA replicationIEA:UniProtKB-KW
Termination of RNA polymerase I transcriptionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Nucleus, nucleolus
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Anti-TTF1 antibodies

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Rabbit Anti-TTF1 Recombinant Antibody (D2E8) (CBMAB-CP2760-LY)

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Target: TTF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D2E8
Application*: WB, IF, IF (IC)
Datasheet SDS

Mouse Anti-TTF1 Recombinant Antibody (IHC414) (CBMAB-MA255-YC)

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Target: TTF1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: IHC414
Application*: P, E, IH
Datasheet SDS

Mouse Anti-TTF1 Recombinant Antibody (CBT4036) (V2LY-0625-LY473)

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Target: TTF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4036
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-TTF1 Recombinant Antibody (CBT4345) (V2LY-0625-LY472)

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Target: TTF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4345
Application*: F
Datasheet SDS

Mouse Anti-TTF1 Recombinant Antibody (CF457) (CBMAB-FT069LY)

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Target: TTF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF457
Application*: ELISA, WB, IHC
Datasheet SDS

Rabbit Anti-TTF1 Monoclonal Antibody (SP141) (CBMAB-R0083-FY)

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Target: TTF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP141
Application*: ELISA
Datasheet SDS

Mouse Anti-TTF1 Recombinant Antibody (CBYJT-5146) (CBMAB-T4724-YJ)

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Target: TTF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBYJT-5146
Application*: E, WB
Datasheet SDS

Mouse Anti-TTF1 Recombinant Antibody (CBYJT-5145) (CBMAB-T4723-YJ)

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Target: TTF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5145
Application*: E, WB, P, IF, IC, F
Datasheet SDS

Mouse Anti-TTF1 Recombinant Antibody (CBYJT-5144) (CBMAB-T4722-YJ)

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Target: TTF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5144
Application*: E, WB, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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