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Mouse Anti-TTF1 Recombinant Antibody (IHC414) (CBMAB-MA255-YC)

Provided herein is a Mouse monoclonal antibody against Transcription Termination Factor 1. The antibody can be used for immunoassay techniques, such as IHC-P, ELISA, IHC. And it gave a positive signal in Lung Adenocarcinoma.
See all TTF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
IHC414
Antibody Isotype
IgG2b, κ
Application
IHC-P, ELISA, IHC (1:100 - 1:200)

Basic Information

Immunogen
Recombinant Human TTF-1
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Tris buffer pH 7.3 - 7.7, 1% BSA, < 0.1% Sodium Azide
Storage
Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

Target

Full Name
TTF1 Transcription Termination Factor 1
Introduction
TTF1 is a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions.
Entrez Gene ID
7270
UniProt ID
Q15361
Alternative Names
Transcription Termination Factor 1; Transcription Termination Factor, RNA Polymerase I; TTF-1; TTF-I; RNA Polymerase I Termination Factor; Transcription Termination Factor I;
Function
Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.
Biological Process
DNA-templated transcription, termination1 PublicationNAS:UniProtKB
Negative regulation of DNA replicationIEA:UniProtKB-KW
Termination of RNA polymerase I transcriptionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Nucleus, nucleolus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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