TXN2
TXN2 is a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. TXN2 may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis.
Full Name
Thioredoxin 2
Function
Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.
Biological Process
Biological Process cell redox homeostasis Source:GO_Central1 Publication
Biological Process cellular response to nutrient levels Source:Ensembl
Biological Process response to axon injury Source:Ensembl
Biological Process response to glucose Source:Ensembl
Biological Process response to hormone Source:Ensembl
Biological Process response to hypoxia Source:Ensembl
Biological Process response to organic cyclic compound Source:Ensembl
Biological Process response to oxidative stress Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Biological Process cellular response to nutrient levels Source:Ensembl
Biological Process response to axon injury Source:Ensembl
Biological Process response to glucose Source:Ensembl
Biological Process response to hormone Source:Ensembl
Biological Process response to hypoxia Source:Ensembl
Biological Process response to organic cyclic compound Source:Ensembl
Biological Process response to oxidative stress Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Cellular Location
Mitochondrion
Involvement in disease
Combined oxidative phosphorylation deficiency 29 (COXPD29):
An autosomal recessive, infantile-onset, neurodegenerative disorder characterized by decreased activities of mitochondrial respiratory complexes I and III, severe cerebellar atrophy, epilepsy, dystonia, optic atrophy, and peripheral neuropathy.
An autosomal recessive, infantile-onset, neurodegenerative disorder characterized by decreased activities of mitochondrial respiratory complexes I and III, severe cerebellar atrophy, epilepsy, dystonia, optic atrophy, and peripheral neuropathy.
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Anti-TXN2 antibodies
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CompareTarget: TXN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYJT-5454
Application*: WB
Target: TXN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYJT-5453
Application*: WB, IP
Target: TXN2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-5452
Application*: IP
Target: TXN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5451
Application*: E
Target: TXN2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-5450
Application*: WB, E, IC, IF
Target: TXN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5449
Application*: E, WB
Target: TXN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5448
Application*: E
Target: TXN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5447
Application*: P, IC, IF
Target: TXN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5446
Application*: WB, E
Target: TXN2
Sensitivity: 0.0093 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: TXN2
Expressed Host: E. coli
Sequence: Amino Acid: 60-166
Tag: His Tag
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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