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USP12

Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity (PubMed:19075014, PubMed:27373336). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035).

Full Name

Ubiquitin Specific Peptidase 12

Function

Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity (PubMed:19075014, PubMed:27373336).
Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014).
In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035).

Biological Process

Biological Process protein deubiquitination Source:UniProtKB2 Publications
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro

Cellular Location

cytosol
nucleoplasm
nucleus

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Anti-USP12 antibodies

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Mouse Anti-USP12 Recombinant Antibody (2A6) (CBMAB-U0044-CQ)

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Target: USP12

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2A6

Application*: WB

Mouse Anti-USP12 (aa 61-251) Recombinant Antibody (1E3) (CBMAB-U0029-CQ)

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Target: USP12

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1E3

Application*: WB

Human Recombinant Usp12, Active protein, GST Tag (V2LY-0526-LY7558)

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Target: Usp12

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: GST Tag

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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