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Mouse Anti-USP12 Recombinant Antibody (2A6) (CBMAB-U0044-CQ)

This product is a mouse antibody that recognizes USP12. The antibody 2A6 can be used for immunoassay techniques such as: WB.
See all USP12 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2A6
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Purity
>95% as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ubiquitin Specific Peptidase 12
Introduction
Activated by interaction with WDR20 and WDR48 through different allosteric mechanisms.
Entrez Gene ID
219333
UniProt ID
O75317
Alternative Names
UBH1; USP12L1
Function
Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity (PubMed:19075014, PubMed:27373336).
Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014).
In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035).
Biological Process
Biological Process protein deubiquitination Source:UniProtKB2 Publications
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
cytosol
nucleoplasm
nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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