VAV2

VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Full Name
VAV2
Function
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
Biological Process
Biological Process angiogenesis Source:UniProtKB-KW
Biological Process cell migration Source:GO_Central1 Publication
Biological Process cellular response to xenobiotic stimulus Source:Reactome
Biological Process Fc-epsilon receptor signaling pathway Source:Reactome
Biological Process Fc-gamma receptor signaling pathway involved in phagocytosis Source:Reactome
Biological Process lamellipodium assembly Source:Ensembl
Biological Process platelet activation Source:Reactome
Biological Process positive regulation of phosphatidylinositol 3-kinase activity Source:Ensembl
Biological Process regulation of cell size Source:UniProtKB1 Publication
Biological Process regulation of GTPase activity Source:UniProtKB1 Publication
Biological Process regulation of small GTPase mediated signal transduction Source:Reactome
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process small GTPase mediated signal transduction Source:Ensembl
Biological Process vascular endothelial growth factor receptor signaling pathway Source:Reactome
Cellular Location
cytoplasm
cytosol
plasma membrane
PTM
Phosphorylated on tyrosine residues in response to FGR activation.
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Anti-VAV2 antibodies

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Rat Anti-VAV2 Recombinant Antibody (CBYY-1306) (CBMAB-1326-YY)

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Target: VAV2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Rat, Human
Clone: CBYY-1306
Application*: WB, IP
Datasheet SDS

Rat Anti-VAV2 Recombinant Antibody (CBYY-1305) (CBMAB-1325-YY)

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Target: VAV2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Rat, Human
Clone: CBYY-1305
Application*: WB, IP
Datasheet SDS

Rabbit Anti-VAV2 Recombinant Antibody (CBYY-1304) (CBMAB-1324-YY)

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Target: VAV2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBYY-1304
Application*: WB, IP, P, IC
Datasheet SDS

Rabbit Anti-VAV2 Recombinant Antibody (C64H2) (CBMAB-1323-YY)

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Target: VAV2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: C64H2
Application*: WB, IP
Datasheet SDS

Mouse Anti-VAV2 Antibody (8B7) (CBMAB-1807CQ)

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Target: VAV2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 8B7
Application*: E, M
Datasheet SDS

Mouse Anti-VAV2 Antibody (6B8) (CBMAB-1806CQ)

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Target: VAV2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 6B8
Application*: E, M
Datasheet SDS

Mouse Anti-VAV2 Antibody (5G9) (CBMAB-1805CQ)

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Target: VAV2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5G9
Application*: E, M
Datasheet SDS

Mouse Anti-VAV2 Antibody (5E5) (CBMAB-1804CQ)

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Target: VAV2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5E5
Application*: E, M
Datasheet SDS

Mouse Anti-VAV2 Antibody (4H8) (CBMAB-1803CQ)

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Target: VAV2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 4H8
Application*: E, M
Datasheet SDS

Mouse Anti-VAV2 Antibody (1D8) (CBMAB-1802CQ)

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Target: VAV2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1D8
Application*: E, M
Datasheet SDS

Mouse Anti-VAV2 Recombinant Antibody (CBT2272) (V2LY-0625-LY248)

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Target: VAV2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2272
Application*: F
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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