Human Recombinant VAV2 protein, SH3 Domain, GST Tag (V2LY-0526-LY7584)

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Basic Information

Expressed Host
E. coli
Protein Species
Human
Tag
GST Tag
Protein Construction
This product is Human Recombinant VAV2 protein, SH3 Domain, GST Tag consist of Amino Acid: 583-655 and predicts a molecular mass of 34 kDa.
Molecule Mass
34 kDa
Protein Domain
SH3 Domain
Sequence
Amino Acid: 583-655
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
Batch dependent.
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
PBS
Preservative
None
Storage
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
More Infomation

Target

Full Name
VAV2
Function
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
Biological Process
Biological Process angiogenesis Source:UniProtKB-KW
Biological Process cell migration Source:GO_Central1 Publication
Biological Process cellular response to xenobiotic stimulus Source:Reactome
Biological Process Fc-epsilon receptor signaling pathway Source:Reactome
Biological Process Fc-gamma receptor signaling pathway involved in phagocytosis Source:Reactome
Biological Process lamellipodium assembly Source:Ensembl
Biological Process platelet activation Source:Reactome
Biological Process positive regulation of phosphatidylinositol 3-kinase activity Source:Ensembl
Biological Process regulation of cell size Source:UniProtKB1 Publication
Biological Process regulation of GTPase activity Source:UniProtKB1 Publication
Biological Process regulation of small GTPase mediated signal transduction Source:Reactome
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process small GTPase mediated signal transduction Source:Ensembl
Biological Process vascular endothelial growth factor receptor signaling pathway Source:Reactome
Cellular Location
cytoplasm
cytosol
plasma membrane
PTM
Phosphorylated on tyrosine residues in response to FGR activation.
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For research use only. Not intended for any clinical use.

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