What is the recommended storage condition for the Mouse Anti-AAV-6 Recombinant Antibody (CBMAB-V208-1403-FY)?

For optimal long-term stability and to preserve antibody activity, we strongly recommend aliquoting the Mouse Anti-AAV-6 Recombinant Antibody (CBMAB-V208-1403-FY) upon receipt and storing it at -20°C or -80°C. Avoiding repeated freeze-thaw cycles is crucial, as this can lead to protein denaturation and reduced binding efficacy. If stored at 4°C for short-term use (e.g., a few weeks), ensure it is in a dark environment. Always consult the product datasheet for the most precise storage instructions.

Does this antibody cross-react with other common AAV serotypes besides AAV6?

The Mouse Anti-AAV-6 Recombinant Antibody (CBMAB-V208-1403-FY) is highly specific for the AAV6 capsid proteins. It is designed to recognize epitopes unique to AAV6, and in our testing, it demonstrates minimal to no cross-reactivity with other commonly used AAV serotypes (e.g., AAV1, AAV2, AAV5, AAV8, AAV9). This high specificity is a key advantage for studies requiring precise differentiation of AAV6 from other serotypes, which is often crucial in gene therapy applications.

Mouse Anti-AAV-6 Recombinant Antibody (V2-503418) (CBMAB-V208-1403-FY)

See all AAV-6 antibodies

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Published Data

Mouse Anti-AAV-6 Recombinant Antibody (CBMW-H1231) (CBMAB-V208-1403-FY) in Neutralize

ADK6 binding and neutralization assays. Neutralization assays for AAV6,in the presence of ADK6. Transduction is normalized to the luciferase signal for WT virus at zero antibody concentration. ...View More

Bennett, A. D., Wong, K., Lewis, J., Tseng, Y. S., Smith, J. K., Chipman, P., ... & Agbandje-McKenna, M. (2018). AAV6 K531 serves a dual function in selective receptor and antibody ADK6 recognition. Virology, 518, 369-376.

Mouse Anti-AAV-6 Recombinant Antibody (CBMW-H1231) (CBMAB-V208-1403-FY) in Dot Blot

Immuno-dot blot analysis of native rAAV capsids of the panel of AAV serotypes 1-12. All rAAV subtypes were purified by AVB chromatography except for rAAV9 and rAAV11, which were purified by sucrose gradient centrifugation. About 1010, 109, and 108 gp of serotype-specific rAAVs were spotted on a nitrocellulose membrane as indicated by the triangles to the right of the panels. The membranes were incubated with a panel of mAbs as depicted to the left of the membrane. Each mAb detects specific conformational epitopes on the surface of defined AAV capsids. Polyclonal antibody VP51 detects all AAV serotypes and served as an internal loading control for 109 gp of each rAAV serotype. ...View More

Mietzsch, M., Grasse, S., Zurawski, C., Weger, S., Bennett, A., Agbandje-McKenna, M., ... & Heilbronn, R. (2014). OneBac: platform for scalable and high-titer production of adeno-associated virus serotype 1-12 vectors for gene therapy. Human gene therapy, 25(3), 212-222.

Datasheet

Summary

Host Animal

Mouse

Specificity

AAV

Clone

V2-503418

Antibody Isotype

IgG2a, κ

Application

ELISA, IF, IHC, Dot

Basic Information

Immunogen

AAV6 capsids

Specificity

AAV

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS

Preservative

None

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction

Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease.

Alternative Names

AAV-6; Adeno-Associated Virus-6

More Infomation

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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