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Mouse Anti-ACSS1 Recombinant Antibody (CBT2156) (V2LY-0625-LY1259)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2156
Antibody Isotype
IgG1
Application
IHC, FC

Basic Information

Immunogen
Purified recombinant fragment of human ACSS1 (AA: 548-689) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Acyl-CoA Synthetase Short Chain Family Member 1
Entrez Gene ID
84532
UniProt ID
Q9NUB1
Function
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity).
Biological Process
Acetate biosynthetic process
Acetyl-CoA biosynthetic process
Acetyl-CoA biosynthetic process from acetate
Ethanol oxidation
Propionate biosynthetic process
Cellular Location
Mitochondrion matrix
PTM
Reversibly acetylated on Lys-642. The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation mediated by the deacetylase SIRT3.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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