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Rabbit Anti-AZU1 Recombinant Monoclonal Antibody (CBFYR0706) (CBMAB-R0706-FY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBFYR0706
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Pro23-Gly247, with N-terminal His Tag.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB0.5-3 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 50% glycerol
Preservative
0.05% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 27-250

Target

Full Name
Azurocidin 1
Introduction
Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
Entrez Gene ID
566
UniProt ID
P20160
Alternative Names
Azurocidin 1; Heparin-Binding Protein; Cationic Antimicrobial Protein CAP37; Cationic Antimicrobial Protein 37; Neutrophil Azurocidin; HHBP; HBP
Function
This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.
Biological Process
Antimicrobial humoral response Source: UniProtKB
Calcium-mediated signaling using intracellular calcium source Source: UniProtKB
Cell chemotaxis Source: UniProtKB
Cellular extravasation Source: UniProtKB
Defense response to Gram-negative bacterium Source: UniProtKB
Defense response to virus Source: UniProtKB
Glial cell migration Source: UniProtKB
Induction of positive chemotaxis Source: UniProtKB
Inflammatory response Source: UniProtKB
Macrophage chemotaxis Source: UniProtKB
Microglial cell activation Source: UniProtKB
Monocyte activation Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Neutrophil degranulation Source: Reactome
Neutrophil-mediated killing of bacterium Source: UniProtKB
Positive regulation of cell adhesion Source: UniProtKB
Positive regulation of fractalkine production Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of interleukin-1 beta production Source: UniProtKB
Positive regulation of MHC class II biosynthetic process Source: UniProtKB
Positive regulation of peptidyl-threonine phosphorylation Source: UniProtKB
Positive regulation of phagocytosis Source: UniProtKB
Positive regulation of protein kinase activity Source: UniProtKB
Positive regulation of tumor necrosis factor production Source: UniProtKB
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Protein kinase C signaling Source: UniProtKB
Proteolysis Source: UniProtKB
Regulation of vascular permeability Source: UniProtKB
Cellular Location
Cytoplasmic granule membrane. Localizes to azurophil granules of neutrophil granulocytes. Also called primary granules, these specialized lysosomes of the neutrophil formed early during promyelocyte development store antibacterial proteins and peptides.
PTM
Cleavage of the N-terminal propeptide which is composed of 7 amino acids occurs in two steps. The initial cleavage of 5 amino acids is followed by the cleavage of a dipeptide to produce the mature form.
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For research use only. Not intended for any clinical use.

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