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Mouse Anti-BCL9L Recombinant Antibody (CBT2543) (V2LY-0625-LY808)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2543
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human BCL9L (AA: 606-751) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
B cell CLL/lymphoma 9-like
Entrez Gene ID
283149
UniProt ID
Q86UU0
Function
Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity).
Biological Process
Beta-catenin-TCF complex assembly Source: Reactome
Canonical Wnt signaling pathway Source: GO_Central
Negative regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of cell morphogenesis Source: BHF-UCL
Skeletal muscle cell differentiation Source: Ensembl
Somatic stem cell population maintenance Source: Ensembl
Cellular Location
Nucleus
More Infomation

Wang, X., Feng, M., Xiao, T., Guo, B., Liu, D., Liu, C., ... & Zhu, D. (2021). BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer. Oncogene, 40(16), 2982-2997.

Lu, M., Qin, X., Zhou, Y., Li, G., Liu, Z., Geng, X., & Yue, H. (2021). Long non-coding RNA LINC00665 promotes gemcitabine resistance of Cholangiocarcinoma cells via regulating EMT and stemness properties through miR-424-5p/BCL9L axis. Cell death & disease, 12(1), 1-17.

Yang, M., Wei, Z., Feng, M., Zhu, Y., Chen, Y., & Zhu, D. (2021). Pharmacological Inhibition and Genetic Knockdown of BCL9 Modulate the Cellular Landscape of Cancer-Associated Fibroblasts in the Tumor-Immune Microenvironment of Colorectal Cancer. Frontiers in oncology, 11.

Huge, N., Sandbothe, M., Schröder, A. K., Stalke, A., Eilers, M., Schäffer, V., ... & Skawran, B. (2020). Wnt status-dependent oncogenic role of BCL9 and BCL9L in hepatocellular carcinoma. Hepatology international, 14(3), 373-384.

Zhang, S., Chen, H., Liu, W., Fang, L., Qian, Z., Kong, R., ... & Cao, X. (2020). miR-766-3p targeting BCL9L suppressed tumorigenesis, epithelial-mesenchymal transition, and metastasis through the β-catenin signaling pathway in osteosarcoma cells. Frontiers in cell and developmental biology, 8, 1086.

Moghe, A., & Monga, S. P. (2020). BCL9/BCL9L in hepatocellular carcinoma: will it or Wnt it be the next therapeutic target?.

Gay, D. M., Ridgway, R. A., Müller, M., Hodder, M. C., Hedley, A., Clark, W., ... & Sansom, O. J. (2019). Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer. Nature communications, 10(1), 1-16.

Sun, R., Liu, Z., Han, L., Yang, Y., Wu, F., Jiang, Q., ... & Huang, C. (2019). miR‐22 and miR‐214 targeting BCL9L inhibit proliferation, metastasis, and epithelial‐mesenchymal transition by down‐regulating Wnt signaling in colon cancer. The FASEB Journal, 33(4), 5411-5424.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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