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Mouse Anti-CD1B Recombinant Antibody (3H647) (CBMAB-C0202-CN)

This product is a Mouse antibody that recognizes CD1B. The antibody 3H647 can be used for immunoassay techniques such as: FC, IHC, IP.
See all CD1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3H647
Antibody Isotype
IgG1
Application
FC, IHC, IP

Basic Information

Immunogen
Human thymocytes
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 1% BSA, before the addition of glycerol to 40%
Preservative
0.09% Sodium azide
Concentration
50 tests/mL

Target

Full Name
CD1b Molecule
Introduction
CD1B (CD1b Molecule) is a Protein Coding gene. Diseases associated with CD1B include Mycobacterium Malmoense and Mycobacterium Tuberculosis 1. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include beta-2-microglobulin binding and endogenous lipid antigen binding. An important paralog of this gene is CD1A.
Entrez Gene ID
910
UniProt ID
P29016
Alternative Names
CD1b Molecule; CD1B Antigen, B Polypeptide; CD1b Antigen; Differentiation Antigen CD1-Alpha-3; T-Cell Surface Glycoprotein CD1b; Cortical Thymocyte Antigen CD1B; CD1A; CD1; R1;
Function
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Regulation of immune response Source: Reactome
Cellular Location
Lysosome membrane; Endosome membrane; Cell membrane. Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.
Topology
Extracellular: 18-303
Helical: 304-324
Cytoplasmic: 325-333

Ween, M. P., White, J. B., Tran, H. B., Mukaro, V., Jones, C., Macowan, M., ... & Hodge, S. J. (2021). The role of oxidised self-lipids and alveolar macrophage CD1b expression in COPD. Scientific reports, 11(1), 1-14.

Guo, J., Jin, H., Xi, Y., Guo, J., Jin, Y., & Jiang, D. (2020). The miR-582/CD1B axis is involved in regulation of dendritic cells and is associated with clinical outcomes in advanced lung adenocarcinoma. BioMed research international, 2020.

Reijneveld, J. F., Ocampo, T. A., Shahine, A., Gully, B. S., Vantourout, P., Hayday, A. C., ... & Van Rhijn, I. (2020). Human γδ T cells recognize CD1b by two distinct mechanisms. Proceedings of the National Academy of Sciences, 117(37), 22944-22952.

Camacho, F., Moreno, E., Garcia-Alles, L., Santiago, G. C., Gilleron, M., Vasquez, A., ... & Acosta, A. (2020). A direct role for the CD1b endogenous spacer in the recognition of a Mycobacterium tuberculosis antigen by T-cell receptors. Frontiers in immunology, 11, 2538.

Shahine, A., Reinink, P., Reijneveld, J. F., Gras, S., Holzheimer, M., Cheng, T. Y., ... & Van Rhijn, I. (2019). A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids. Nature communications, 10(1), 1-12.

Lee, C. H., Chen, L. C., Yu, C. C., Lin, W. H., Lin, V. C., Huang, C. Y., ... & Bao, B. Y. (2019). Prognostic value of CD1B in localised prostate cancer. International journal of environmental research and public health, 16(23), 4723.

Shahine, A. (2018). The intricacies of self-lipid antigen presentation by CD1b. Molecular immunology, 104, 27-36.

Chancellor, A., Tocheva, A. S., Cave-Ayland, C., Tezera, L., White, A., Juma’a, R., ... & Mansour, S. (2017). CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains. Proceedings of the National Academy of Sciences, 114(51), E10956-E10964.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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