CD1B
CD1B (CD1b Molecule) is a Protein Coding gene. Diseases associated with CD1B include Mycobacterium Malmoense and Mycobacterium Tuberculosis 1. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include beta-2-microglobulin binding and endogenous lipid antigen binding. An important paralog of this gene is CD1A.
Full Name
CD1b Molecule
Function
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Regulation of immune response Source: Reactome
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Regulation of immune response Source: Reactome
Cellular Location
Lysosome membrane; Endosome membrane; Cell membrane. Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.
Topology
Extracellular: 18-303
Helical: 304-324
Cytoplasmic: 325-333
Helical: 304-324
Cytoplasmic: 325-333
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Anti-CD1B antibodies
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CompareTarget: CD1B
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-303, 1-119
Tag: His Tag
Target: CD1B
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-303
Tag: hFc Tag
Target: CD1B
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-303, 1-119
Tag: His Tag
Target: CD1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2377
Application*: F
Target: CD1B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT2457
Application*: F
Target: CD1B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: MT-101
Application*: F, IP, IF
Target: CD1B
Host: Mouse
Antibody Isotype: IgM
Specificity: Sheep, Cattle, Goat
Clone: CBXC-0182
Application*: F, IF, IP, WB
Target: CD1B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Sheep, Cattle
Clone: CBXC-0181
Application*: F
Target: CD1B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-1308
Application*: E
Target: CD1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SN13
Application*: F, IH, IP
Target: CD1B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Dog, Cattle, Goat, Horse
Clone: CBXC-2336
Application*: F, IH, IP
Target: CD1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Sheep, Cattle, Goat
Clone: CBYY-C0638
Application*: F, IP, IF
Target: CD1B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E4
Application*: E
Target: CD1B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: O249
Application*: F, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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