Mouse Anti-CD1B Recombinant Antibody (CBXC-0181) (CBMAB-C4794-CQ)

Name: Mouse Anti-CD1B Recombinant Antibody (CBXC-0181)
SKU: CBMAB-C4794-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXC-0181

Application

Immunogen

Thymocytes of bovine origin.

Host Species

Mouse

Specificity

Sheep, Cattle

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

CD1b Molecule

Introduction

CD1B (CD1b Molecule) is a Protein Coding gene. Diseases associated with CD1B include Mycobacterium Malmoense and Mycobacterium Tuberculosis 1. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include beta-2-microglobulin binding and endogenous lipid antigen binding. An important paralog of this gene is CD1A.

Entrez Gene ID

910

UniProt ID

P29016

Function

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Biological Process

Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Regulation of immune response Source: Reactome

Cellular Location

Lysosome membrane; Endosome membrane; Cell membrane. Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.

Topology

Extracellular: 18-303
Helical: 304-324
Cytoplasmic: 325-333

Ween, M. P., White, J. B., Tran, H. B., Mukaro, V., Jones, C., Macowan, M., ... & Hodge, S. J. (2021). The role of oxidised self-lipids and alveolar macrophage CD1b expression in COPD. Scientific reports, 11(1), 1-14.

Guo, J., Jin, H., Xi, Y., Guo, J., Jin, Y., & Jiang, D. (2020). The miR-582/CD1B axis is involved in regulation of dendritic cells and is associated with clinical outcomes in advanced lung adenocarcinoma. BioMed research international, 2020.

Reijneveld, J. F., Ocampo, T. A., Shahine, A., Gully, B. S., Vantourout, P., Hayday, A. C., ... & Van Rhijn, I. (2020). Human γδ T cells recognize CD1b by two distinct mechanisms. Proceedings of the National Academy of Sciences, 117(37), 22944-22952.

Camacho, F., Moreno, E., Garcia-Alles, L., Santiago, G. C., Gilleron, M., Vasquez, A., ... & Acosta, A. (2020). A direct role for the CD1b endogenous spacer in the recognition of a Mycobacterium tuberculosis antigen by T-cell receptors. Frontiers in immunology, 11, 2538.

Shahine, A., Reinink, P., Reijneveld, J. F., Gras, S., Holzheimer, M., Cheng, T. Y., ... & Van Rhijn, I. (2019). A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids. Nature communications, 10(1), 1-12.

Lee, C. H., Chen, L. C., Yu, C. C., Lin, W. H., Lin, V. C., Huang, C. Y., ... & Bao, B. Y. (2019). Prognostic value of CD1B in localised prostate cancer. International journal of environmental research and public health, 16(23), 4723.

Shahine, A. (2018). The intricacies of self-lipid antigen presentation by CD1b. Molecular immunology, 104, 27-36.

Chancellor, A., Tocheva, A. S., Cave-Ayland, C., Tezera, L., White, A., Juma’a, R., ... & Mansour, S. (2017). CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains. Proceedings of the National Academy of Sciences, 114(51), E10956-E10964.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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