Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-CD1B Recombinant Antibody (CBT2457) (V2LY-0625-LY885)


See all CD1B antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2457
Antibody Isotype
IgG2b
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human CD1B (AA: extra 18-303) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD1b Molecule
Entrez Gene ID
910
UniProt ID
P29016
Function
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Regulation of immune response Source: Reactome
Cellular Location
Lysosome membrane; Endosome membrane; Cell membrane. Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.
Topology
Extracellular: 18-303
Helical: 304-324
Cytoplasmic: 325-333
More Infomation

Ween, M. P., White, J. B., Tran, H. B., Mukaro, V., Jones, C., Macowan, M., ... & Hodge, S. J. (2021). The role of oxidised self-lipids and alveolar macrophage CD1b expression in COPD. Scientific reports, 11(1), 1-14.

Guo, J., Jin, H., Xi, Y., Guo, J., Jin, Y., & Jiang, D. (2020). The miR-582/CD1B axis is involved in regulation of dendritic cells and is associated with clinical outcomes in advanced lung adenocarcinoma. BioMed research international, 2020.

Reijneveld, J. F., Ocampo, T. A., Shahine, A., Gully, B. S., Vantourout, P., Hayday, A. C., ... & Van Rhijn, I. (2020). Human γδ T cells recognize CD1b by two distinct mechanisms. Proceedings of the National Academy of Sciences, 117(37), 22944-22952.

Camacho, F., Moreno, E., Garcia-Alles, L., Santiago, G. C., Gilleron, M., Vasquez, A., ... & Acosta, A. (2020). A direct role for the CD1b endogenous spacer in the recognition of a Mycobacterium tuberculosis antigen by T-cell receptors. Frontiers in immunology, 11, 2538.

Shahine, A., Reinink, P., Reijneveld, J. F., Gras, S., Holzheimer, M., Cheng, T. Y., ... & Van Rhijn, I. (2019). A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids. Nature communications, 10(1), 1-12.

Lee, C. H., Chen, L. C., Yu, C. C., Lin, W. H., Lin, V. C., Huang, C. Y., ... & Bao, B. Y. (2019). Prognostic value of CD1B in localised prostate cancer. International journal of environmental research and public health, 16(23), 4723.

Shahine, A. (2018). The intricacies of self-lipid antigen presentation by CD1b. Molecular immunology, 104, 27-36.

Chancellor, A., Tocheva, A. S., Cave-Ayland, C., Tezera, L., White, A., Juma’a, R., ... & Mansour, S. (2017). CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains. Proceedings of the National Academy of Sciences, 114(51), E10956-E10964.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CD1B Recombinant Antibody (CBT2457)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry