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Mouse Anti-CEACAM3 Recombinant Antibody (417009) (CBMAB-C1272-LY)

This product is antibody recognizes CEACAM3. The antibody 417009 immunoassay techniques such as: WB.
See all CEACAM3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
417009
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human CEACAM-3/CD66d isoform 1, Lys35-Gly155, Accession # P40198
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Carcinoembryonic Antigen Related Cell Adhesion Molecule 3
Introduction
This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]
Entrez Gene ID
1084
UniProt ID
P40198
Alternative Names
Carcinoembryonic Antigen Related Cell Adhesion Molecule 3; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3; Carcinoembryonic Antigen CGM1; CD66d Antigen; CD66D; CGM1;
Function
Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.
Biological Process
Leukocyte migration Source: Reactome
Cellular Location
Membrane
Topology
Extracellular: 35-155
Helical: 156-176
Cytoplasmic: 177-252
PTM
Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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